Process of extracting mannitol using glucose mother liquid

A technology of glucose mother liquor and mannitol, which is applied in the directions of blood diseases, extracellular fluid diseases, fermentation, etc., can solve the problems of unretrieved mannitol method, immature high-purity fructose technology, and incompatibility with industrialized large-scale production, etc. The effect of production cost, increasing added value and improving utilization rate

Inactive Publication Date: 2009-09-16
SHANDONG XIWANG SUGAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3. Using fructose as raw material: after hydrogenation of fructose, a mixed alcohol of mannitol and sorbitol is obtained, and mannitol can be obtained by crystallization, with a theoretical yield of 50%, but the price of fructose is relatively high, and domestic production The technology of high-purity fructose is immature, so the production of mannitol from pure fructose or high-purity fructose does not meet the requirements of large-scale industrial production
[0009] 6. Using glucose as raw material: epimerizing glucose into mannose (the conversion rate is generally 27% to 33%) and hydrogenating invert sugar to obtain a mixture of about 30% mannitol and sorbitol, which is produced by crystallization To obtain mannitol products, this method has industrialized production equipment, but the yield is not high, only reaching 24% to 26%
But, in the method for preparing mannitol involved in the prior art, do not find the report of utilizing glucose mother liquor to prepare mannitol method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) 5L of glucose mother liquor A (dry matter 52.4%, from Shanxi Xiwang Sugar Industry Co., Ltd.), diluted with deionized water to a dry matter weight percentage concentration of 30%, is then filtered through a nanofiltration membrane device to obtain a concentration of 20.5% respectively The glucose-rich component B and the concentration of 32.75% oligosaccharide-rich component C;

[0041] (2) Adjust the pH of oligosaccharide-rich component C to 4.3 with hydrochloric acid, saccharify at 58°C for 55 hours, then combine with glucose mother liquor A, repeat mother liquor A nanofiltration→saccharification of C liquor→saccharify with glucose mother liquor A Merge→the steps of (1) and (2) of mother liquor A nanofiltration again;

[0042] (3) The glucose-rich component B obtained in the step (1) is deionized through cation exchange resin AmberliteIRC76CRF+Amberlite FPRC22Na, anion exchange resin Amberlite FPA51+Amberlite FPA90C1; then vacuum concentration to dry matter weight...

Embodiment 2

[0049] (1) Dilute 5L of glucose mother liquor A (dry matter 60%) with deionized water to a dry matter weight percentage concentration of 35%, then filter the nanofiltration membrane device to obtain the glucose-rich component B and the oligosaccharide-rich group respectively share C;

[0050] (2) Adjust the pH of oligosaccharide-rich component C to 4.5 with hydrochloric acid, saccharify at 60°C for 45 hours, then combine with glucose mother liquor A, and then repeat nanofiltration of mother liquor A → saccharification of liquid C → saccharification with glucose mother liquor A Merge→the steps of (1) and (2) of mother liquor A nanofiltration again;

[0051] (3) The glucose-rich component B obtained in the step (1) is deionized through cation exchange resin AmberliteIRC76CRF+Amberlite FPRC22Na, anion exchange resin Amberlite FPA51+Amberlite FPA90C1; then vacuum concentration to dry matter weight percent concentration is 60%; Add 1.5% molybdate catalyst by relative dry matter we...

Embodiment 3

[0057] (1) Dilute 5L glucose mother liquor A (dry matter 50%) with deionized water to a dry matter weight percent concentration of 25%, and then filter a nanofiltration membrane device to obtain respectively a glucose-rich component B and an oligosaccharide-rich group share C;

[0058] (2) Adjust the pH of oligosaccharide-rich component C to 4.2 with hydrochloric acid, saccharify at 55°C for 55 hours, then combine with glucose mother liquor A, and then repeat nanofiltration of mother liquor A → saccharification of liquid C → saccharification with glucose mother liquor A Merge→the steps of (1) and (2) of mother liquor A nanofiltration again;

[0059] (3) The glucose-rich component B obtained in the step (1) is deionized through cation exchange resin AmberliteIRC76CRF+Amberlite FPRC22Na, anion exchange resin Amberlite FPA51+Amberlite FPA90Cl; then vacuum concentration to dry matter weight percent concentration is 40%; Add 2% molybdate catalyst by relative dry matter weight to t...

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PUM

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Abstract

The invention discloses a method for preparing mannitol by utilizing a glucose mother liquor. The steps are: (1) after diluting the glucose mother liquor A, carry out nanofiltration to obtain a glucose-rich component B and an oligosaccharide-rich component C; ( 2) After saccharification of component C, it is combined with mother liquor A, and the steps of (1) and (2) are repeated again; (3) after the separation and concentration of component B obtained in (1), the epimerization reaction is carried out. Obtaining the mixed solution D of glucose and mannose; (4) adding glucose crystal seeds to the mixed solution D to crystallize the glucose to obtain wet crystals and sugar solution E; (5) passing the sugar solution E through the glucose isomerase column to carry out isoformation. Structural reaction to obtain mixed sugar solution F of mannose, glucose and fructose; (6) hydrogenation reaction is carried out after mixing mixed sugar solution F with crystalline fructose mother liquor to obtain mixed alcohol G; (7) mixed alcohol G is filtered, Isolation, concentration, crystallization, centrifugation and drying to obtain mannitol. The invention uses the mother liquor as the raw material, which greatly reduces the production cost and improves the utilization rate of the raw material.

Description

technical field [0001] The invention relates to a method for preparing hexahydric alcohol, in particular to a method for preparing mannitol from glucose mother liquor. Background technique [0002] Mannitol is a commonly used dehydrating drug and diuretic, which can reduce intracranial pressure and intraocular pressure, eliminate cerebral edema, diuresis and prevent early acute renal insufficiency. The preparation is mannitol injection. In the food industry, mannitol stearate is used in peanut pulp to prevent oil separation, used in biscuits to make biscuits crisp and not easy to be affected by moisture, used in candies to set the shape and improve the quality of candies. In daily chemical industry, mannitol is used as an emulsifier in creams, which can make creams delicate. In engineering, it is an important material for heat preservation and sound insulation. [0003] There are mainly following methods for preparing mannitol in industry: [0004] 1. Kelp extraction meth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/18A61P7/10
Inventor 王勇李伟阿纳斯孙宗宝滕俊强杨会敏崔立平
Owner SHANDONG XIWANG SUGAR
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