Wound suturing-free tissue adhesive

A wound and antibacterial agent technology, applied in the field of medical and health materials, can solve the problems of accelerating the polymerization reaction of tissue glue, prolonging the polymerization time of the tissue glue polymer film, and low solubility.

Inactive Publication Date: 2009-10-07
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned added antibacterial agent, deodorant have the following disadvantages: 1. under room temperature (being 20-25 ℃) in solubility in α-cyanoacrylate alkyl ester; 3. Accelerate the polymerization of tissue glue on the skin wound, so that it is too late to apply the tissue glue to the entire wound; 4. Prolong the appropriate polymerization time of the tissue glue polymer film on the skin wound and other shortcomings

Method used

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  • Wound suturing-free tissue adhesive
  • Wound suturing-free tissue adhesive
  • Wound suturing-free tissue adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The composition and content of the wound suture-free tissue glue of the present invention are as follows:

[0048] Alpha-amyl cyanoacrylate 10

[0049] Decyl alpha-cyanoacrylate 20

[0050] Polybutylmethacrylate 0.5

[0051] Dibutyl phthalate 1.0

[0052] Angelica essential oil 0.05

[0053] Chlorhexidine iodine 0.1

[0054] The preparation method of the wound suture-free tissue glue of the present invention is obtained by uniformly mixing the above-mentioned components according to their contents.

Embodiment 2

[0056] The composition and content of the wound suture-free tissue glue of the present invention are as follows:

[0057] Ethyl α-cyanoacrylate 40

[0058] Polyethyl methacrylate 2

[0059] Polyoctyl methacrylate 0.5

[0060] Diethyl phthalate 1.0

[0061] Dibutyl phthalate 1.0

[0062] Angelica essential oil 0.4

[0063] Cinnamon Oil 0.6

[0064] erythromycin ethylsuccinate 0.5

[0065] Acetylspiramycin 0.5

[0066] The preparation method of the wound suture-free tissue glue of the present invention is obtained by uniformly mixing the above-mentioned components according to their contents.

Embodiment 3

[0068] The composition and content of the wound suture-free tissue glue of the present invention are as follows:

[0069] Ethyl α-cyanoacrylate 20

[0070] α-Propyl cyanoacrylate 20

[0071] Butyl alpha-cyanoacrylate 20

[0072] n-octyl alpha-cyanoacrylate 20

[0073] Polymethylmethacrylate 2.5

[0074] Polyethyl methacrylate 2.5

[0075] Polyvinyl acetate 2.5

[0076] Diethyl phthalate 1.5

[0077] Dibutyl phthalate 2.5

[0078] Di-n-octyl phthalate 1

[0079] Dipropyl sebacate 1.5

[0080] Angelica essential oil 6

[0081] cinnamon oil 5

[0082] Myrrh Essential Oil 2

[0083] Pioneer Metabolite 7

[0084] Cefixime 6

[0085] Tobramycin 6

[0086] Erythromycin 3.5

[0087] The preparation method of the wound suture-free tissue glue of the present invention is obtained by uniformly mixing the above-mentioned components according to their contents.

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Abstract

The wound-free tissue glue of the invention belongs to the medical and health field, and in particular relates to an alpha-cyanoacrylate alkyl ester tissue glue containing an antibacterial agent and a deodorant. The invention contains 40.0-85.0 parts of α-cyanoacrylate alkyl ester, 0.7-6.5 parts of strength improving agent, 0.5-7.5 parts of plasticity improving agent, 0.1-22.5 parts of antibacterial agent and 0.02-9.5 parts of deodorant. Among them, the antibacterial agent is one or more of Pioneer Metabolite, erythromycin ethylsuccinate, acetylspiramycin, and chlorhexidine iodine; the deodorant is one or more of angelica essential oil, cinnamon oil, and myrrh essential oil. species or two or more. The wound suture-free tissue glue of the present invention has antibacterial properties, can obviously reduce its peculiar odor, and is widely used in the field of wound suture-free.

Description

technical field [0001] The invention belongs to the field of medical and sanitary materials, and in particular relates to an α-cyanoacrylate alkyl ester wound-free tissue glue containing high-efficiency antibacterial components and deodorizing components. Background technique [0002] Surgical and traumatic wounds are usually closed using three methods: sutures, staples, and tissue glue. [0003] Tissue glue bonding method, that is, α-alkyl cyanoacrylate tissue glue closing wound method, has unique characteristics of bonding wounds. α-Alkyl cyanoacrylate tissue glue is widely used as a seam-free tissue glue to close surgical wounds and traumatic wounds, especially for wounds that are difficult to close satisfactorily with suture, it saves time and energy, and can bond difficult-to-suture wounds. tissue, can provide a relatively airtight environment for wound closure, no need to change dressings after surgery, has the effect of hemostasis, the wound is more beautiful after h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10
Inventor 樊粤光孙鸿涛阮传良王海彬
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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