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Children's anti-epilepsy agent

A kind of medicine and children's technology, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc.

Inactive Publication Date: 2007-08-15
TIANJIN HONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dosage forms involved in the above two documents are decoctions and powders, which belong to the traditional traditional Chinese medicine dosage forms and cannot meet the clinical requirements. Modern pharmaceutical methods and advanced technologies are required to classify the medicinal taste of the prescription according to the properties of the active ingredients contained in it. Maximize the extraction of active ingredients and refine them into modern Chinese patent medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Relevant pharmacological test research and clinical trial research data on the formulation of Pediatric Antiepileptic Capsules:

[0081] Pharmacodynamic study of Xiaoer Kangxian Capsules:

[0082] Abstract: Xiaoer Kangxian Capsule 20~10g / kg was given to mice by intragastric administration, and it had a very significant antagonistic effect on the convulsions caused by the method of "penetrazol convulsions in mice and strychnine convulsions in mice". And has a certain dose-dependent relationship.

[0083] experiment material:

[0084] Drug: Pediatric Antiepileptic Capsule provided by Tianjin Hongrentang Pharmaceutical Co., Ltd. Add an appropriate amount of water to the capsule powder, decoct in the same way, filter through gauze, and concentrate the filtrate to the required concentration (0.133g / ml, 0.2g / ml, 0.267g / ml). Batch numbers: 870104, 870105, 870106. Pentetrazole injection (source: Xinya Pharmaceutical Factory); nitroazepam (source: Tianjin Haiguang Pharmaceut...

Embodiment 2

[0105] Example 2: Summary of Phase II Clinical Trial of Xiaoer Kangxian Capsules in Treating Epilepsy in Children (Syndrome of Wind-phlegm Obstruction):

[0106] Unit in charge of clinical trials: Xiyuan Hospital, China Academy of Traditional Chinese Medicine

[0107] Clinical experiment units: Xiyuan Hospital of China Academy of Traditional Chinese Medicine, Beijing Children's Hospital, Tianjin Hospital of Traditional Chinese Medicine, Department of Traditional Chinese Medicine of Tianjin Medical University General Hospital

[0108] Xiaoer Kangeile Capsules (hereinafter referred to as Kangeile Capsules) is an effective prescription for treating children with epilepsy (wind-phlegm obstruction syndrome) based on 50 years of clinical experience summed up by Professor Li Shaochuan of Tianjin College of Traditional Chinese Medicine. It was developed by Tianjin No. 5 Traditional Chinese Medicine Factory into a new drug of traditional Chinese medicine (three categories). According ...

Embodiment 3

[0317] Take the raw materials according to the following weight ratio:

[0318] 10 parts of Dannanxing, 10 parts of Radix Pseudostellariae, 10 parts of Pinellia (made in China), 15 parts of Iris Calamus, 3 parts of Amber, 10 parts of Liushenqu (stir-fried with bran), 6 parts of Chuanxiong, 6 parts of Gastrodia elata, 10 parts of Poria cocos, 6 parts of orange red, 15 parts of green fruit, 3 parts of agarwood, 6 parts of aurantium husk (stir-fried with bran), 6 parts of notopterygium

[0319] Preparation method: 1. Dannanxing, Jiujiechangpu, amber, agarwood, Liushenqu (stir-fried with bran), Gastrodia elata, Chuanxiong, and notopterygium, crushed into fine powder, sieved (24 mesh), and set aside;

[0320] 2. Add the remaining six flavors of Pseudostellaria Pseudostellariae and other six flavors to decoct 3 times, the first time for 3 hours, the second time for 2 hours, the third time for 1 hour, filter in several times, combine the filtrates, concentrate to a relative density o...

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PUM

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Abstract

The invention discloses a medicament for treating children's epilepsy which is a capsule prepared from the following Chinese medicinal herbs (by weight portion): Arisaema cum Bile 10 parts, pseudostellaria root 10 parts, pinellia tuber 10 parts, anemone rhizome 15 parts, amber 3 parts, rhizome of Sichuan lovage 6, gastrodia elata 6 parts, poria cocos wolf 10 parts, dried tangerine peel 6 parts, Chinese olive 15 parts, ligumaloes 3 parts, bitter orange 6 parts and notopterygium root 6 parts.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to an antiepileptic drug for treating children with epilepsy. Background technique [0002] Epilepsy, also commonly known as "sheep epilepsy wind", has a variety of Chinese and Western medicines for the treatment of epilepsy. Beijing Traditional Chinese Medicine, 1988 (1) recorded "Clinical Observation and Experimental Research of 73 Cases of Infantile Epilepsy mainly Treated with Kangxian Powder", No. 32-33 The powder prescription is recorded on the page: Pseudostellariae, Dannanxing, Banxia, ​​Jiujiechangpu, Amber, Divine Comedy, Chuanxiong, Gastrodia elata, Poria cocos, orange red, green fruit, agarwood, aurantium, notopterygium, functions and indications: epilepsy syndrome in children. However, its ratio has not been disclosed. [0003] In addition, there are powder prescriptions mentioned in Tianjin Traditional Chinese Medicine, "P...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/48A61P25/08A61K35/10
Inventor 朱晓晶王齐李凤阁宋文霞
Owner TIANJIN HONGRENTANG PHARM CO LTD
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