Method for ex-vivo purging in autologous transplantation
A technology of autologous transplantation and ligands, applied in biochemical equipment and methods, biological agents for removing bad cells, cells modified by introducing foreign genetic material, etc.
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[0108] MegaFasL induces high levels of apoptosis in hematological malignancies
[0109] IC determined from PESMTS assay 50 shown in Figure 3. Values represent means (±SEM) of 3 independent experiments. ND = no data available; resistance = IC 50 Fas agonist concentrations up to 10,000 ng / ml were not achieved.
[0110] disease
cell name
MegaFasL
IC 50 (ng / ml)
CH11
IC 50 (ng / ml)
sFasL M2
IC 50 (ng / ml)
ARH-77
RPMI-8226
U266
OPM2
10.4±0.19
3.57±0.68
6.20±1.50
2.19±1.53
resistance
resistance
resistance
ND
136±12.0
ND
39.9±10.1
ND
acute myeloid leukemia
HL60(AML-M3)
NB4 (AML-M3)
213±126
16.0±3.18
resistance
resistance
ND
resistance
acute T lymphoblastic leukemia
Jurkat
0.06±0.03
6.58±2.57
6.36±1.93
Burkitt Lymphoma
...
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