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Clerodendranthus spiatus extract for treating urinary calculus and its prepn process

An extract and technology of kidney tea, applied in the field of kidney tea anti-urinary calculus extract and its preparation, can solve problems such as difficult to cure kidney stones, degeneration of kidney tissue, and infiltration of inflammatory cells

Inactive Publication Date: 2007-11-07
ZHEJIANG SUB TROPICS CROP INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of urinary stones, especially kidney stones, mainly uses extracorporeal shock wave lithotripsy (ESWL) and endourological surgery, which often cause kidney damage and serious complications, which can cause renal tissue degeneration and produce glomerulus. Hyalinosis and fibrosis, interstitial congestion, inflammatory cell infiltration, and ESWL and surgical treatment are difficult to cure kidney stones, and the postoperative recurrence rate is about 78% to 80% higher

Method used

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  • Clerodendranthus spiatus extract for treating urinary calculus and its prepn process
  • Clerodendranthus spiatus extract for treating urinary calculus and its prepn process
  • Clerodendranthus spiatus extract for treating urinary calculus and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1: (preparation 1 of kidney tea extract A component)

[0066] The preparation of the kidney tea extract A component is carried out in the following steps:

[0067] (1) Grind the dry product of kidney tea [C.spicatus (Thunb.) C.Y.Wu ex H.W.Li] and soak it in methanol for 3 times at the ratio of weight (g): volume (ml) = 1:4, each time After 10 days, the combined extracts were distilled and concentrated under reduced pressure under the control of water temperature at 60°C to obtain the extract mixture;

[0068](2) Mix the dissolving liquid of step (1) extract mixture and water-methanol by 1:5 volume by weight (g):volume (ml)=1:1 ratio, stir until fully dissolved;

[0069] (3) Extract the liquid extract solution of step (2) 4 times with petroleum ether to fully remove low-polarity impurity components such as resins and chlorophyll, then extract 4 times with ethyl acetate, merge and concentrate the extract;

[0070] (4) The extract in step (3) was subjected to ...

Embodiment 2

[0071] Embodiment 2: (preparation 2 of kidney tea extract A component)

[0072] In this preparation example, the dry product of kidney tea is pulverized and soaked in methanol at a ratio of weight (g): volume (ml) = 1:7; the combined extracts are concentrated by vacuum distillation under the control of water temperature at 50°C; water- Methanol was mixed at a volume of 1:9 to form a solution; chromatography, elution, and collection were concentrated by vacuum distillation under the control of water temperature at 50°C, and the rest of the preparation steps and process conditions were the same as in Example 1.

Embodiment 3

[0073] Embodiment 3: (preparation 3 of kidney tea extract A component)

[0074] In this preparation example, the dry product of kidney tea is pulverized and soaked in methanol at a ratio of weight (g): volume (ml) = 1:10; the combined extracts are concentrated by vacuum distillation under the control of water temperature at 40°C; water- Methanol was mixed at a volume of 1:12 to form a solution; chromatography, elution, and collection were concentrated by vacuum distillation under the control of water temperature at 40°C, and the rest of the preparation steps and process conditions were the same as in Example 1.

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Abstract

The present invention discloses clerodendranthus spiatus extract for treating urinary calculus and its preparation process, and belongs to the field of Chinese herbal medicine extract and application technology. The clerodendranthus spiatus extract preparing process includes the following steps: soaking clerodendranthus spiatus in 4-10 times methanol to extract and concentrating to obtain extractum; dissolving the extractum in solvent in the same volume; extracting the solution first with petroleum ether and then with ethyl acetate and concentrating to obtain coarse extract; and chromatographic separation, eluting, collecting and concentrating to operate clerodendranthus spiatus extract A. The clerodendranthus spiatus extract A is liposoluble flavone glycoside compound and has obvious urinary calculus treating effects.

Description

【Technical field】 [0001] The invention relates to the technical field of extracts and applications of Chinese herbal medicines, in particular to kidney tea anti-urinary calculi extracts and a preparation method thereof. 【Background technique】 [0002] Kidney stones, bladder stones, urinary calculi, etc. are common diseases of the urinary system. It is reported in the literature that the incidence is 5% to 9% in Europe, 12% in Canada, about 13% in the United States, and about 9% to 15% in my country. The incidence of urinary stones is as high as 20%. The incidence increases with age, and the risk also increases. Areas with hotter climates and people who eat animal protein, especially young and middle-aged men aged 30 to 50, have a higher incidence rate, with a male to female ratio of 2 to 3:1. Epidemiological surveys in recent years have shown that the incidence rate is on the rise, especially among young and middle-aged people, which has seriously affected people's health. ...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P13/04
Inventor 陶正明蔡华芳顾雪萍李林
Owner ZHEJIANG SUB TROPICS CROP INST
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