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Preparation for treating hepatic encephalopathy and preparation method thereof

A technology for hepatic encephalopathy and liver disease, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, nervous system diseases, etc., can solve the problems of not combining, and achieve the goal of improving memory impairment and inhibiting the rise of blood ammonia Effect

Inactive Publication Date: 2007-11-28
CLINICAL PHARMACY INST OF BEIJING MUNICIPAL HEALTH BUREAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Insufficiency of western medicine treatment: Lactulose and lactitol are the ideal medicines for the treatment of hepatic encephalopathy.
Whether it is western medicine or traditional Chinese medicine, there is no combination of detoxification, liver protection, refreshing and nootropic preparations for chronic mild hepatic encephalopathy caused by liver cirrhosis and liver failure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Preparation method: take storax and rehmannia glutinosa according to the formula ratio of 1:90, add 10 times of water to rehmannia, decoct 3 times, half an hour each time, filter the decoction, concentrate under reduced pressure to a thick ointment with a specific gravity of 1.25; 12-fold cyclodextrin inclusion compound, filtered to obtain the inclusion compound, and rehmannia thick ointment and storax inclusion compound were mixed to form a thick ointment.

Embodiment 2

[0050] Preparation method: take storax and rehmannia glutinosa according to the formula ratio of 1:60, add 10 times of water to rehmannia, decoct twice, 1 hour each time, filter the decoction, concentrate under reduced pressure, spray dry into powder; Cyclodextrin clathrate, filter to obtain clathrate, mix rehmannia dry powder and styrax clathrate, and make pills.

Embodiment 3

[0052] Preparation method: take storax and rehmannia glutinosa according to the formula ratio of 1:25, add 10 times of water to rehmannia, decoct 3 times, half an hour each time, filter the decoction, concentrate under reduced pressure, dry under low temperature and reduced pressure to become powder; Include with 8 times cyclodextrin, dry at 40°C to form powder; mix the two dry powders, add appropriate amount of lactose, and extrude to make granules.

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Abstract

The present invention discloses one kind of medicine for treating hepatic diseases and hepatic encephalopathy. The medicine is prepared with rehmannia root and storax as main material, and through decocting rehmannia root, concentrating and drying to obtain rehmannia powder; including storax with cyclodextrin and drying to obtain storax powder, and mixing rehmannia powder, storax powder and proper amount of supplementary material. Animal experiment and clinical application show that the medicine has functions of lowering blood ammonia, protecting liver and promoting intelligence growth.

Description

Technical field: [0001] The invention relates to the field of medicine and provides a compound pharmaceutical preparation for treating liver disease, liver cirrhosis and hepatic encephalopathy and a preparation method thereof. The preparation is made of rehmannia glutinosa and storax, and pharmaceutically acceptable auxiliary materials can be added if necessary. Background technique: [0002] Hepatic encephalopathy (hepatic encephalopathy, HE) is a metabolic disorder-based central nervous system dysfunction syndrome caused by severe liver disease. According to clinical manifestations, hepatic encephalopathy is divided into four stages. The first stage (prodromal stage) is characterized by mild personality changes and behavioral disturbances, and sometimes the symptoms are not obvious and are easily ignored. The second stage (pre-coma) is mainly characterized by confusion, sleep disturbance, and behavioral disturbance. The third period is the drowsy period, and the fourth p...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P1/16A61P25/00
Inventor 罗燕燕侯晓明龚韬朱青张薇薇索建政
Owner CLINICAL PHARMACY INST OF BEIJING MUNICIPAL HEALTH BUREAU
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