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Slow release coating layer of degradable medication for bracket of coronary artery

A drug and sustained-release technology, which is applied in the field of medical materials to achieve good biocompatibility, prevent and inhibit restenosis of blood vessels, and prevent release.

Inactive Publication Date: 2007-12-26
天津市凯迪亚医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention overcomes the deficiencies of the prior art and provides a polymer carrier-degradable drug slow-release coating for coronary stents, thereby solving a series of problems caused by polymer carriers remaining in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The drug uses rapamycin, the biodegradable polymer carrier is polylactic acid-glycolic acid (PLGA) polymer, the molar ratio n(dl-LA) / n(GA) is 85 / 15, and the molecular weight is 600000. The weight ratio of the pamycin to the polymer carrier is 1:6.

Embodiment 2

[0023] The drug uses rapamycin, the biodegradable polymer carrier is polylactic acid-glycolic acid (PLGA) polymer, the molar ratio n(dl-LA) / n(GA) is 90 / 10, the molecular weight is 45000, and the molecular weight is 45000. The weight ratio of the pamycin to the polymer carrier is 1:3.

Embodiment 3

[0025] The drug adopts paclitaxel, the biodegradable polymer carrier is polylactic acid-glycolic acid (PLGA) copolymer, the molar ratio n(dl-LA) / n(GA) is 50 / 50, the molecular weight is 75000, paclitaxel and polymer The weight ratio of the carrier is 1:10.

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PUM

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Abstract

The present invention relates to a coronary scaffold degradable medicine slow-release coating layer. Its main technique is characterized by that its used medicine is rapamycin, taxol, tacrolimus, taxotere and dexamethasone, and the used polymer carrier can be biodegradable polylactic acid-glycollic acid (PLGA) polymer, PLA, PLLA,PDLA, PDLLA, PGA, PEG and copolymer of above-mentioned polymers and mixture of above-mentioned polymer and copolymer, the above-mentioned polymers, copolymer and mixture can be used as carrier of degradable medicine, in which the weight ratio of above-mentioned medicine and polymer carrier is 1:3-1:10.

Description

technical field [0001] The invention relates to a coronary stent in the field of medical materials, in particular to a degradable drug slow-release coating for a coronary stent. Background technique [0002] Coronary artery stenting is a coronary intervention technique, and it is currently one of the fastest and most effective methods for treating coronary stenosis. Its biggest disadvantage is the high rate of restenosis. This is because the stent will cause damage to the local vascular intima during the release process, thereby stimulating the proliferation of vascular intima tissue and causing restenosis; and the implantation of the stent is a foreign body for the human body, which will cause an inflammatory response, and Long-term contact of stents with blood may lead to thrombus formation, stimulate the proliferation of smooth muscle cells, and cause restenosis of blood vessels. [0003] In order to overcome the above shortcomings, a drug-coated stent has been developed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/50
Inventor 陈伊卫余少炀曲刚
Owner 天津市凯迪亚医疗器械有限公司
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