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Pharmaceutical composition of compound fat-soluble vitamin and method of preparing the same

A vitamin and composition technology, which is applied in the field of pharmaceutical compositions and their preparation, can solve the problems such as the decrease in the content of complex fat-soluble vitamins, and achieve the effect of ensuring safety

Active Publication Date: 2008-02-27
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention aims to solve the problem that the content of complex fat-soluble vitamins drops sharply after sterilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: the preparation of injection

[0057] Take 100ml of water for injection, 0.05g of calcium sodium edetate and 22g of glycerin, mix them evenly, heat to about 40-60°C, add 12g of lecithin and stir to disperse to obtain solution 1; mix vitamin A 99mg, vitamin D 2 0.5mg, vitamin E 0.91g, vitamin K 1 Add 15 mg to 100 parts by weight of soybean oil, stir evenly to obtain solution 2; mix solution 1 and solution 2 to form a primary emulsion, add water to 1000ml, emulsify through a high-pressure homogenizer, adjust pH, filter, fill, and cap , sterilized to obtain an injectable emulsion.

Embodiment 2

[0058] Embodiment 2: the preparation of injection

[0059] Take 100ml of water for injection, 0.025g of calcium sodium edetate and 22g of glycerin, mix them evenly, heat to about 40-60°C, add 12g of lecithin and stir to disperse to obtain solution 1; mix vitamin A 99mg, vitamin D 2 0.5mg, vitamin E 0.91g, vitamin K 1 Add 15 mg to 100 parts by weight of soybean oil, stir evenly to obtain solution 2; mix solution 1 and solution 2 to form a primary emulsion, add water to 1000ml, emulsify through a high-pressure homogenizer, adjust pH, filter, fill, and cap , sterilized to obtain an injectable emulsion.

Embodiment 3

[0060] Embodiment 3: the preparation of injection

[0061] Take 100ml of water for injection, 0.001g of calcium sodium edetate and 22g of glycerin, mix them evenly, heat to about 40-60°C, add 12g of lecithin and stir to disperse to obtain solution 1; mix vitamin A 99mg, vitamin D 2 0.5mg, vitamin E 0.91g, vitamin K 1 Add 15 mg to 100 parts by weight of soybean oil, stir evenly to obtain solution 2; mix solution 1 and solution 2 to form a primary emulsion, add water to 1000ml, emulsify through a high-pressure homogenizer, adjust pH, filter, fill, and cap , sterilized to obtain an injectable emulsion.

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PUM

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Abstract

The invention discloses a drug composition of compound liposoluble vitamin, which comprises the following parts: vitamin A, vitamin D2, vitamin E, vitamin K1, metal ion chelant (ethylenediamine tetra-acetic acid salt). The invention can be made into injecting emulsion to solve the problem to generate degrading product in the preparing and sterilizing course, which ensures the security of clinic drug.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a fat-soluble vitamin pharmaceutical composition and a preparation method thereof. Background technique [0002] Fat-soluble vitamins are one of the indispensable components of parenteral nutrition to meet the daily requirements of fat-soluble vitamin A and vitamin D for adults. 2 , vitamin E, vitamin K 1 physiological needs. Fat-soluble vitamin injections were prepared according to the prescription amount, and vitamin A, vitamin E, and vitamin D were used for fat-soluble vitamin injections before and after sterilization. 2 and vitamin K 1 Assays were carried out, and the results showed that vitamin D 2 and vitamin K 1 The content after sterilization is only about 47.1% and 7.7% of that before sterilization. [0003] The invention aims to solve the problem that the content of complex fat-soluble vitamins drops sharply after sterilization. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/592A61K9/107A61K47/18A61K47/44A61P3/02A61K31/07A61K31/122A61K31/355
Inventor 王利春孔繁贵胡思玉余启波罗琴张德奎梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD
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