'Zanyudan' oral preparation and preparation thereof

A technology of oral preparation and zanyudan, applied in the field of medicine, can solve the problems of inaccurate dosage, inability to commercialize, large dosage of traditional Chinese medicine decoction, etc.

Inactive Publication Date: 2008-08-13
张文芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the original preparation is used as a whole powder, the active ingredients of the medicine cannot be well absorbed. After research, the compound is extracted through the compound recipe, and quantitatively controlled by the index components to make a modern oral preparation of traditional Chinese medicine. The dosage of the product is accu...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment one: "Zan Yudan" extract 1 (extract) preparation method

[0051] Prescription: 24 grams of Rehmannia glutinosa, 12 grams each of Cistanche, Morinda officinalis, Epimedium, and Eucommia, 6 grams of Cnidium, 12 grams of leek seeds, 18 grams of Angelica, 12 grams of curculigo, 6 grams of aconite, 24 grams of Atractylodes macrocephala, wolfberry 18 grams of cornel, 12 grams of dogwood, 6 grams of cinnamon

[0052] Preparation method: cleanly select the medicinal materials of the prescription, weigh each medicinal material according to the prescription amount, add 6 to 15 times the amount of water to soak for 2-10 hours, heat and boil for 2-3 times, and combine the extracts; the water extracts stand still After 12-48 hours, filter the supernatant, concentrate under reduced pressure to obtain about 30.4 g of water extract.

Embodiment 2

[0053] Embodiment two: "Zan Yudan" extract 2 (dry powder) preparation method

[0054] Prescription: 24 grams of Rehmannia glutinosa, 12 grams each of Cistanche, Morinda officinalis, Epimedium, and Eucommia, 6 grams of Cnidium, 12 grams of leek seeds, 18 grams of Angelica, 12 grams of curculigo, 6 grams of aconite, 24 grams of Atractylodes macrocephala, wolfberry 18 grams of cornel, 12 grams of dogwood, 6 grams of cinnamon

[0055] Preparation method: cleanly select the medicinal materials of the prescription, weigh each medicinal material according to the prescription amount, add 8 to 10 times the amount of water to soak for 2-8 hours, heat to boiling and extract 2-3 times, combine the extracts; the water extracts stand still After 12-48 hours, the supernatant was collected by filtration, concentrated under reduced pressure, and spray-dried to obtain about 32.8 g of water extract as a dry powder.

Embodiment 3

[0056] Embodiment three: "Zan Yudan" oral solid preparation preparation method

[0057] (1) Preparation of "Zanyudan" granules

[0058] prescription:

[0059] "Zanyudan" Extract 1 10-90%

[0060] Starch 5.0-70%

[0061] Dextrin 2.0-20%

[0062] Xylitol 5.0-20%

[0063] Methyl sorbate 0.001-2.0%

[0064] Preferred Prescription:

[0065] "Zanyudan" extract 1 30.4g

[0066] Starch 3.0g

[0067] Dextrin 3.0g

[0068] Xylitol 2.0g

[0069] Methyl sorbate 0.002g

[0070] Preparation method: Prepare the extract of "Zanyudan" according to the method in Example 1, add the prescribed amount of auxiliary materials to make granules according to the conventional method, dry at low temperature, pack and make three bags, each bag is 12.8g.

[0071] (2) Preparation of "Zan Yudan" tablet:

[0072] (1) Ordinary tablet prescription:

[0073] "Zanyudan" Extract 2 5.0-90%

[0074] Starch 5.0-50%

[0075] Dextrin 2.0-20%

[0076] Microcrystalline Cellulose 5.0-20%

[0077] Talc 0...

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PUM

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Abstract

The present invention relates to a zanyudan medicine oral liquid preparation and a method for preparing the same. The preparation is prepared from mixed extract (extractum or dry powder) including rehmanniae vaporata, largehead atractylodes rhizome, angelica, medlar, eucommia bark, common curculigo rhizome, baji fruit, cornus officinalis, barrenwort, cistanche, chinese chive seed, cnidium monnieri, aconite, cinnamon as raw materials, and acceptable carrier or excipient as substrate in medicine by conventional process. The preparation has effects of strengthening yang, warm supplying below body, breeding seed for treating excessive sexual life, decline of vital gate-fire, deficient kidney essence, impotence and premature ejaculation, pale complexion, energy loss, dizziness tinnitus, soreness-tired of waist and knee, fear of cold, pale tongue with whitish fur, deep and thin pulse, male sterile caused by yang deficiency and defective ejaculation. The long term clinical appliance shows that the medicine has better treating effects for insufficiency of kidney yang, decline of vital gate-fire, deficiency-cold without child.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral preparation for mainly treating male impotence, sperm failure, asthenia-cold infertility and a preparation method thereof, in particular to an oral preparation using the extract of Zanyudan traditional Chinese medicine prescription as the active ingredient of the medicine. Background technique [0002] "Zan Yu Dan" was created by Zhang Jingyue in the Ming Dynasty in "Jingyue Quanshu". Composed of dogwood, epimedium, cistanche, leek seed, cnidium, aconite, and cinnamon, it has the effects of nourishing essence and strengthening yang, warming and nourishing energy, and promoting seeds. Premature ejaculation, pale complexion, listlessness, dizziness, tinnitus, soreness of waist and knees, aversion to cold, pale tongue with thin white fur, deep and thready pulse can also treat infertility caused by yang deficiency and less essence. Insufficiency of yang, decline...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61K47/20A61K47/36A61K47/40A61K47/44A61P15/10A61P1/14
Inventor 张文芳曹世栋
Owner 张文芳
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