Liquid phase micro- extraction on-line preliminary treatment device for capillary pipe electrophoresis-ampere detector and its usage method

A technology of capillary electrophoresis and pretreatment device, applied in the field of chemical analysis, can solve the problems of inability to combine liquid-phase microextraction online, unsatisfactory reproducibility, stability, unsatisfactory treatment effect, etc., and achieve good chemical stability, Avoid contamination and systematic errors, low cost effect

Inactive Publication Date: 2008-11-19
FUZHOU UNIV
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  • Abstract
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Problems solved by technology

[0005] However, in the prior art, the liquid phase microextraction pretreatment method for samples is inconvenient, the processing effect is not ideal, the processing is not fast, the matrix has many interferences, the detection sensitivity is low, the reproducibility and stability are not ideal, and it cannot The online combination of liquid phase microextraction and capillary electrophoresis and many other defects

Method used

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  • Liquid phase micro- extraction on-line preliminary treatment device for capillary pipe electrophoresis-ampere detector and its usage method
  • Liquid phase micro- extraction on-line preliminary treatment device for capillary pipe electrophoresis-ampere detector and its usage method

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Embodiment

[0046] Porous polypropylene hollow fiber tube is used, and the fiber pore size is generally 0.2 μm; the liquid-phase micro-suction device is a syringe with a needle; one end of the U-shaped hollow fiber tube is sleeved at about 2 mm from the front end of the needle of the liquid-phase micro-suction device ; The capillary and the platinum electrode are immersed in the other end of the U-shaped hollow fiber tube at about 10 mm; the stirring device is a magnetic stirrer; the sample container is a 2mL cylindrical flat-bottomed glass bottle with a rubber stopper.

[0047] 1. On-line liquid phase microextraction

[0048] (1) First add 1 mL of sample to a cylindrical flat-bottomed narrow-necked glass bottle with a rubber stopper, then add 0.5 mL of acid (or alkali) solution to adjust the pH of the sample solution so that the target extract exists as a neutral molecule, and then add a magnetic stir bar Stir to combine.

[0049] (2) Aspirate the receiving phase solution with a liquid-...

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Abstract

The invention provides a liquid phase micro-extraction device for complex matrix sample on-line pretreatment of a capillary electrophoresis-ampere detector as well as a usage method thereof, a liquid phase micro-pumping device of the device is fixed on a fixed mount, the lower end of the liquid phase micro-pumping device is nested with a section of U-shaped hollow fiber pipe, and a capillary sample inlet end and an electrode are inserted into the other end of the hollow fiber pipe, the U-shaped hollow fiber pipe is positioned in a sample container, and a stirring device is also arranged on the sample container; and the liquid phase micro-extraction in the complex matrix sample pretreatment can be implemented according to the device of the invention. The invention has a complex matrix sample liquid phase micro-extraction pretreatment device, a capillary electrophoresis device and an ampere detector connected together to form an integral device, the range of detected substances is extended, and the sensitivity, reproducibility, stability and reliability for separating capillary electrophoresis are improved; and the device has advantages of small volume, simple structure, simple operating method, low cost, good reproducibility of the method, and convenient sample analysis after pretreatment.

Description

technical field [0001] The invention belongs to the field of chemical analysis, and more specifically relates to a liquid-phase micro-extraction online pretreatment device for a capillary electrophoresis-ampere detector and a use method thereof. Background technique [0002] Capillary electrophoresis (Capillary electrophoresis, CE) is a new type of chromatographic separation technology that is driven by a high-voltage electric field and uses a quartz capillary as a separation channel to achieve separation by utilizing the difference in electrophoretic mobility between the components of the sample. , trace and other advantages. At present, capillary electrophoresis technology has been widely used in pharmaceutical analysis, environmental analysis, life science analysis and other fields. However, due to the small inner diameter of the general capillary (less than 100 μm) and the small injection volume, the detection sensitivity is low, which is far from meeting the requiremen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/34G01N27/447G01N35/00
Inventor 张兰郑丽辉童萍陈国南
Owner FUZHOU UNIV
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