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Medicament for treating chronic renal failure and production method

A technology for treating drugs and renal function, applied in the field of drug calcium, can solve the problems of reducing curative effect, increasing cost, increasing side effects, etc., and achieves good effect.

Active Publication Date: 2009-01-21
SHANDONG TIANSHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After calcination or roasting, the cost is increased, the curative effect is reduced, and the side effects of Na+ and Mg2+ on patients with renal insufficiency are relatively increased.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 1 kg of montmorillonite, soak it in 5000 ml of 1% calcium chloride solution, stir continuously, keep at room temperature for 30 hours, filter to remove water, wash with water until the pH value is 6.8-9, filter to remove water, and then use 30% calcium chloride solution Soak 5000 ml once, stir continuously, keep at room temperature for 5 hours, filter to remove water, wash with water until the pH value is 6.8-9, filter to remove water, dry, crush to obtain calcium-based montmorillonite, add appropriate amount of glucose to make powder.

Embodiment 2

[0023] Take 1 kg of montmorillonite, soak it in 4500 ml of 30% calcium chloride solution, stir constantly, keep the temperature at 50°C for 3 hours, filter to remove water, wash with water until the pH value is 6.8-9, filter to remove water, and then use 10% chlorine Soak once in 4500 ml of calcium chloride solution, stir constantly, keep the temperature at 50°C for 5 hours, filter to remove water, wash with water until the pH value is 6.8-9, filter to remove water, dry, and pulverize to obtain calcium-based montmorillonite. The pharmaceutical excipients are made into tablets according to conventional preparation methods.

Embodiment 3

[0025] Take 1 kg of montmorillonite, soak it in 5000 ml of 5% calcium chloride solution, stir constantly, keep the temperature at 80°C for 4 hours, filter to remove water, wash with water until the pH value is 6.8-9, filter to remove water, and then use 5% chlorine Soak once in 5000 ml of calcium chloride solution, stir constantly, keep the temperature at 80°C for 4 hours, filter to remove water, wash with water until the pH value is 6.8-9, filter to remove water, dry, and pulverize to obtain calcium-based montmorillonite. The pharmaceutical excipients are made into capsules according to conventional preparation methods.

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PUM

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Abstract

The invention relates to a medicine for curing chronic renal failure and a production method thereof, which is characterized in that the medicine is calcium-base samoite excluding K+, Na+, Mg2+ and other exchangeable cations. The preparation method includes immersing the samoite in calcium chloride solution and then exchanging ions. After oral administration, toxins in the alimentary tract of patients with chronic renal failure is absorbed by samoite of the medicine and then discharged out of the body along with intestinal peristalsis, thus achieving intestinal hemodialysis. While absorbing and fixing the toxins in the alimentary tract, the calcium-base samoite has no side effect on patients of Na and K restriction without releasing K+, Na+, Mg2+ and other exchangeable cations.

Description

technical field [0001] The invention relates to medicine calcium, in particular to a medicine for treating chronic renal failure and a production method thereof. technical background [0002] Montmorillonite is a typical 2:1 layered silicate mineral containing crystal water, which has many excellent properties such as high dispersion, suspension, swelling, cohesiveness, adsorption, and cation exchange. Montmorillonite has a very high positioning ability. After oral administration, the drug can evenly cover the entire surface of the intestinal cavity and last for 6 hours. Montmorillonite can adsorb a variety of pathogens and digestive tract endotoxins, fix them on the surface of the intestinal cavity, and then excrete them with intestinal peristalsis, thereby avoiding the damage of various pathogens and digestive tract endotoxins to the body. [0003] It is recorded in the famous medical book "Supplements to Materia Medica" of the Tang Dynasty in my country: "Sweet soil is n...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K9/14A61K9/48A61K9/20A61K9/10A61K9/16A61P13/12
Inventor 张为胜李诗标张梅雪张晶徐东峰
Owner SHANDONG TIANSHUN PHARMA
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