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Compositions and methods for modulating the immune system

A composition and compound technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, blood diseases, etc., can solve the problem of long cost

Inactive Publication Date: 2009-01-21
帕特里克·T·普伦德加斯特
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although bone marrow can functionally revert to producing blood cell components at levels produced before radiation exposure, this reversion may take up to 3 months

Method used

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  • Compositions and methods for modulating the immune system
  • Compositions and methods for modulating the immune system
  • Compositions and methods for modulating the immune system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0367] Materials and methods

[0368] Riboflavin, nitroblue tetrazolium (NBT), reduced glutathione (GSH), S-S′-dithiobis(2-nitrobenzoic acid) (DTNB), and 1-chloro-2 , 4-Dinitrobenzene (CDNB) was obtained from Sisco Research Laboratories Pvt. Ltd, Mumbai, India. Thiobarbituric acid was purchased from Hi-media laboratories, Mumbai, India, and 1,1,3,3-tetramethoxypropane was supplied by Sigma-Aldrich USA. All other chemicals and reagents used in this study were of analytical grade. Oltipraz was supplied by contractor Canopus Corporation.

[0369] Inbred 4-6 week old female Swiss albino mice (20-30 g) were obtained from a small animal vivarium, Kerala Agricultural University, Mannuthy, Thrissur. Animals were maintained in well-ventilated cages under standard conditions of temperature, pressure and humidity. Animals were provided normal mouse chow and water ad libitum. All animal experiments performed during this study were pre-approved and followed the guidelines of the Ins...

Embodiment 2

[0383] Example 2 - Patient Case Study

[0384] Patients are treated with the compound of formula 2 and blood cell parameters are monitored. The experiment has a sample size of 1 and consists of subject 1. Subject 1, an immunocompromised patient who suffered from multiple recurrent infectious episodes requiring hospitalization, was initiated in a near-moribund state with the experimental drug isopentenyladenosine (IPA).

[0385] The subject has been hospitalized for a life-threatening infection. During the three months prior to hospitalization, the subject's total white blood cell count was in the range of 2200-4900. A T4 / T8 cell ratio of 50 / 270 (0.22) was observed during the first two months. The patient was hospitalized with depression, exhaustion, bronchial infection, severe diarrhea, severe weight loss, and complete loss of appetite and intensified fever (high fever, spiked fever). The patient weighed 98 lbs.

[0386] Although initially very cooperative for patients ...

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PUM

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Abstract

The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.

Description

technical field [0001] The present invention relates to methods for stimulating cellular production (production) of leukocytes. In particular, the present invention provides compositions and methods for enhancing blood cell production. In particular, the compounds, compositions and methods of the invention can be used to ameliorate or treat conditions such as neutropenia, thrombocytopenia, anemia and other blood cell deficiencies, or other exemplary conditions such as reactive oxidative stress (the cause of which caused by or caused by exposure to gamma rays, X-rays, or proton radiation). Background technique [0002] Suppression or dysregulation (dysregulation) of the immune system can be a component of many pathological diseases or conditions. In particular, dysregulation of the immune system can lead to disease onset and progression. In the context of a disease flare, dysregulation of the immune system refers to the lack of immunity in an individual and the inability t...

Claims

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Application Information

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IPC IPC(8): A61K31/497A61K31/52A61P7/00
Inventor 帕特里克·T·普伦德加斯特
Owner 帕特里克·T·普伦德加斯特