Uses of curcurbitacin in producing medicament for treating cancer

The invention relates to a technology for the treatment of cecillin, which is applied to the application field of cecilin in the preparation of medicines for treating cancer, and can solve the problems of reports that the application of cecilin has not yet been found.

Inactive Publication Date: 2009-05-13
KUNMING LONGJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the

Method used

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  • Uses of curcurbitacin in producing medicament for treating cancer
  • Uses of curcurbitacin in producing medicament for treating cancer
  • Uses of curcurbitacin in producing medicament for treating cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: Get 5kg at the bottom of the bamboo pot in Qiaojia County, Yunnan, grind it into middle powder, fill it in the seepage container, at 15-25°C, add 24 times the amount of acetone to soak for 48 hours, then carry out the percolation method by the Chinese Pharmacopoeia Roll, recover the percolation liquid, mix the extract into an equal amount of silica gel, dry at 50-70 ° C, put on a silica gel column, use chloroform: methanol as the eluent to carry out gradient elution, and collect the eluent at a concentration of 3-5% methanol. After dehydration and recovery, the crude product can be obtained, and recrystallized several times with methanol to obtain columnar crystals with a melting point of 226-228°C and a purity of 98.98% by HPLC analysis. As shown in Figure 1, it was confirmed to be bilbacetin through four-spectrum analysis of ultraviolet, infrared, nuclear magnetic resonance and mass spectrometry.

[0058] Taking the above-mentioned pectin as a monomer co...

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Abstract

The invention relates to new application of dihydrocucurbitacin F-25-O-acetate in preparation of medicines for treating cancer. The invention also relates to the application of dihydrocucurbitacin F-25-O-acetate in preparation of medicines for treating leucocythemia.

Description

[0001] This application is a divisional application of 200610010906.7, the filing date of the original application is May 19, 2006, the application number is 200610010906.7, and the name of the invention is: the preparation method of pectin and its application in the preparation of drugs for treating cancer technical field [0002] The invention relates to a preparation method of the medicinal ingredient gentamicin and its new application in the preparation of medicines for treating cancer. Background technique [0003] Echobilisin is a mixture consisting of escobilin and escobilin. It was first isolated from the root of Hemsleya amalils Diels by Chen Weixin et al. (Acta Chemica Sinica, 1975, 33(1), 5). Hemsleya amalils was identified as 19-carbo-9β-formazan 23.24- cc dihydro-25-acetate, B identified as the 23,24-dihydro compound of cucurbitacin F (Ic), two new compounds, and the development of snow gallin tablets, which were recorded in 1974 According to the drug standard...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P35/00C07J9/00
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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