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Preparation process and application of tryptanthrin injection emulsion

A technology for tryptanthrin and injection, which is applied in the field of pharmaceutical manufacturing and its clinical application, and can solve problems such as no specific therapeutic drugs and harm to health

Inactive Publication Date: 2012-01-18
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially tumors, the number of deaths due to cancer in the world is as high as 6 million every year, and the number of new cases exceeds 8 million, and the incidence rate is still increasing year by year; while colitis and fungal infection seriously endanger people's health, and there is no specific treatment drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] specific implementation plan

[0010] The tryptanthrin series of preparations use plant extracts or industrially synthesized tryptanthrin as the main medicinal raw material to prepare tryptanthrin injection emulsions. The specific preparation processes are introduced as follows.

[0011] Emulsion for tryptanthrin injection: The raw material formula of the emulsion for tryptanthrin injection is composed of 0.1-1.0% tryptanthrin, 1.0-4.0% soybean lecithin, 1.5-4.0% cholesterol, and 97.4-91.0% phosphate buffer. The preparation process is as follows: mix tryptanthrin, soybean lecithin and cholesterol, add an appropriate amount of chloroform to dissolve, form a film on a rotary evaporator, drain the chloroform, put the dry film in phosphate buffer solution and ultrasonically dissolve it completely, and then Add phosphate buffer solution to 1000 ml, filter and sterilize with ultra-filtration membrane, pack in 200-500 sterilized control bottles, press the cap, and seal to obta...

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PUM

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Abstract

The invention provides a medicament for treating leucocythemia and other tumors, colonitis and fungal infection, namely a tryptanthrin injection emulsion, and a preparation process thereof, and belongs to the fields of pharmaceutical manufacture and clinical application. The tryptanthrin injection emulsion is characterized in that: tryptanthrin has the effects of killing and inhibiting tumor cells, transplanted tumors in animals, various fungi and bacteria, an effect of inhibiting inflammation, as well as regulation and other pharmacological activities to the immunity of a body. The tryptanthrin injection emulsion prepared by the tryptanthrin for treating leucocythemia and other tumors, colonitis and fungal infection can be used for treating the leucocythemia and other tumors, colonitis, fungal infection and other diseases. The tryptanthrin injection emulsion has the advantages of stable medicament, controllable quality, high bioavailability, small administration dosage, exact curative effect, low side response, rich raw material source and low production cost.

Description

Technical field [0001] The invention relates to tryptanthrin injection emulsion for treating tumor, colitis and fungal infection. The invention belongs to the field of pharmaceutical manufacturing and its clinical application. Background technique [0002] Tryptanthrin can be isolated and extracted from some blue-producing plants such as indigo, Polygonum indigo, Isatis indica, etc. and some microorganisms. Tryptanthrin mainly has anti-cancer, anti-inflammatory, anti-fungal and other activities. Tryptanthrin is a yellow needle-like crystal with a melting point of 267-369°C and a molecular formula of C 15 h 8 N 2 o 2 , can now be artificially synthesized, and the content of industrial products is as high as 97-99%. [0003] Tumor, colitis and fungal infection are clinical common and frequently-occurring diseases. Especially tumors, the number of deaths due to cancer in the world is as high as 6 million every year, and the number of new cases exceeds 8 million, and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/519A61P35/00A61P35/02A61P31/10A61P1/00A61P29/00
Inventor 王四旺杨倩谢艳华缪珊孙纪元王剑波
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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