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Cynoglossum extract, preparation and use thereof

The technology of the inverted pot and the extract is applied in the field of the inverted pot extract and its preparation, which can solve the problems of directly using plants as medicines, cannot be synthesized by other methods, and is not suitable for preparing dosage forms, and achieves novel structure, The effect of promoting modernization, strong biological activity

Inactive Publication Date: 2009-08-12
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its aerial part is also called dog shit flower, dog tongue flower, blue sarong, blue flower ginseng, small green grass, etc., and its underground part has different names such as chicken feet ginseng, dog shit flower root, elderberry root, etc.; Used as medicine, it tastes bitter, cool in nature, clears heat and promotes dampness, dissipates blood stasis and stops bleeding, relieves cough, and relieves pain. It is a national medicine for urethritis and other diseases, but the effective chemical components of the inverted pot herbal medicine have not been reported in the literature so far. Therefore, the use of this herbal medicine in the treatment of diseases only stays at the stage of directly using plants as medicine, which can neither be quantified nor used by other medicines. Synthetic by way of synthesis, not suitable for preparation into the dosage form of modern medicine

Method used

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  • Cynoglossum extract, preparation and use thereof
  • Cynoglossum extract, preparation and use thereof
  • Cynoglossum extract, preparation and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Preparation of Inverted Acid: The medicinal materials used in this example were purchased from the market of traditional Chinese medicinal materials and identified by Mr. Liu Jizhu from the School of Chinese Materia Medica, Guangdong University of Pharmacy. Thin-layer chromatography and column chromatography silica gel were products of Qingdao Ocean Chemical Factory, and the reagents used were analytically pure.

[0021] Dry and pulverize 10Kg of the whole herb in the inverted pot, and extract it with water for 3 times, each time for 2-3 hours; combine the extracts, concentrate, add ethanol to adjust to 75% for alcohol precipitation, filter and remove the precipitate after standing for 24 hours, and the supernatant Recover ethanol until there is no alcohol smell, add appropriate amount of water to dilute, extract with chloroform, ethyl acetate and n-butanol respectively, and recover the solvent to obtain the extract. The n-butanol extract was roughly divided with D101 m...

Embodiment 2

[0032] Sixty Kunming mice were weighed and randomly divided into a control group, a carbon tetrachloride liver injury model group and a treatment group, with 20 mice in each group, and were reared routinely. The mice in the control group and the model group were fed with 0.1% Tween 80 solution, and the administration group was fed with 20 mg / kg of echinocheteric acid (suspension prepared with 0.1% Tween 80), once a day, continuously After 7 days of administration, both the model group and the administration group received ip 0.1% CCl at one time. 4 (prepared with peanut oil, 0.1mL / 10g), after 12h, the eyeballs were picked to take blood, and the serum was taken to measure the corresponding indicators. The results showed that compared with the carbon tetrachloride liver injury model group, the serum ALT and AST of the mice in the administration group decreased significantly (p<0.05 and p<0.01), the activity of SOD increased and the MDA decreased significantly (p<0.05 and p<0.01)...

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Abstract

The invention relates to a cynoglossum extract with the molecular of C30H44O8. The invention also provides a preparation method of the cynoglossum extract, which comprises the following steps of: drying and crushing cynoglossum herb and backflowing with water; carrying out depositing in alcohol after the extracting solution is concentrated, filtering precipitates, recovering the alcohol with supernatant fluid, adding proper amount of water for diffusion, and respectively using chloroform, ethyl acetate and normal butanol for extraction, recovering a solvent to obtain extract; and obtaining the cynoglossum extract after the extract is purified. The invention also provides an application of the cynoglossum extract in the pharmaceutical field. The cynoglossum extract belongs to new chemical entity, and belongs to original innovation; the compound is novel in structure, and has strong biologic activity by analysis of structure-activity relationship; the invention defines the effective components in the cynoglossum extract, leads the cynoglossum extract to be capable of being utilized by modern pharmaceutical dosage form, further enhances the modernization of traditional medicines and has wide application prospect.

Description

technical field [0001] The present invention relates to an extract of inverted teapot and its preparation method and application, belonging to the technical field of pharmacy. Background technique [0002] Cynoglossum amabile Stapf et Drumm, a perennial herb of the Boraginaceae family, is distributed in Yunnan, Guizhou, Guangdong, Guangxi, Xinjiang and other places in my country. Its aerial part is also called dog shit flower, dog tongue flower, blue sarong, blue flower ginseng, small green grass, etc., and its underground part has different names such as chicken feet ginseng, dog shit flower root, elderberry root, etc.; Used as medicine, it tastes bitter, cool in nature, clears heat and promotes dampness, dissipates blood stasis and stops bleeding, relieves cough, and relieves pain. It is a national medicine for urethritis and other diseases, but the effective chemical components of the inverted pot herbal medicine have not been reported in the literature so far. Therefore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K31/56A61P1/16
Inventor 党丽娟李坤平徐庆军张德志
Owner GUANGDONG PHARMA UNIV
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