Use of Brassica rapa polysaccharide in preparation of anti-hypoxia drugs

An anti-hypoxia and coriander root technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, anti-toxins, etc., can solve the problems of unknown active parts, product quality can not be effectively controlled, etc., to achieve simple methods and low production costs. The effect of low and high polysaccharide content

Inactive Publication Date: 2009-09-09
西藏自治区高原生物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent "method for preparing products with anti-hypoxia and anti-fatigue functions by using coriander roots" (patent application number: 200710090934.9) only directly prepares coriander root juice obtained after washing, peeling, pre-cooking and beating coriander roots for anti-hypoxia product, but its active part is unknown, and the quality of the prepared product cannot be effectively controlled

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]Take an appropriate amount of dried and crushed coriander root, heat it to reflux with 5 times the amount of distilled water, and extract 3 times. The extraction time is 3, 2 and 1 hour respectively. The three extracts are combined and filtered with a 150-mesh double-layer filter cloth. The filtrate is at 70°C. Use thin film evaporation to concentrate to 1 / 3 of the original volume; under stirring, add 5 times 75% ethanol to the concentrated extract to precipitate the polysaccharide in the concentrated extract, and collect the polysaccharide crude precipitate of Daphne root polysaccharide; to the crude polysaccharide precipitation Add distilled water to dissolve it to make it fully reconstituted. Use the sevag method to remove the protein. Repeat for 9 times and concentrate (the method is the same as above). Add 5 times 75% methanol to the concentrated solution for alcohol precipitation, precipitation with absolute ethanol, Wash with acetone and diethyl ether to obtain the de...

Embodiment 2

[0044] Take an appropriate amount of dried and crushed coriander root, heat it to reflux with 20 times the amount of distilled water, and extract 4 times. The extraction time is 3, 2 and 1 hour respectively. The three extracts are combined and filtered with a 100 mesh double-layer filter cloth. The filtrate is at 50°C. Use thin film evaporation to concentrate to 1 / 5 of the original volume; under stirring, add 2 times 95% ethanol to the concentrated extract to precipitate the polysaccharide in the concentrated extract, and collect the polysaccharide crude precipitate of Daphne root polysaccharide; to the crude polysaccharide precipitation Add distilled water to dissolve it to make it fully reconstituted, remove protein by sevag method, repeat 3 times, concentrate (the method is the same as above), add 3 times 85% methanol to the concentrated solution for alcohol precipitation, precipitation with absolute ethanol, Wash with acetone and ether to obtain the deproteinized polysaccharid...

Embodiment 3

[0048] Take an appropriate amount of dried and crushed coriander root and soak it in 5 times the amount of distilled water for 2 hours. Under the processing conditions of microwave power of 600W, material-to-liquid weight ratio of 1:5, and microwave extraction time of 2 minutes, the residue is added after one microwave extraction Soak the same volume of water for another 1 hour, and then extract twice by microwave; combine the two extracts, filter with 150 mesh double-layer filter cloth, and concentrate the filtrate under reduced pressure at 70℃ to 1 / 3 of the original volume; concentrate the extract under stirring Add 5 times 75% ethanol to the concentrated extract to precipitate out the polysaccharides in the concentrated extract, and collect the crude polysaccharides of Daphne root polysaccharides; add distilled water to the crude polysaccharides to dissolve them and make them fully reconstituted. Use the sevag method to remove the protein. Repeat Perform 9 times, concentrate (t...

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PUM

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Abstract

The invention relates to a usage of Brassica rapa polysaccharide which is extracted from Brassica rapa plants in the preparation of anti-hypoxia drugs, the average molecular weight of the Brassica rapa polysaccharide is 30,000-80,000, and the total polysaccharide content is 60-95 percent by weight. The Brassica rapa polysaccharide can be prepared into pharmaceutical acceptable formulations, such as granules, oral liquid, capsules, tablets, injections or powder. The Brassica rapa polysaccharide obtained by the method has available raw materials, simple method, low production cost, high polysaccharide content in the product, stable quality and easy control. The Brassica rapa polysaccharide has obvious anti-hypoxia activity. The Brassica rapa polysaccharide can be used for preparing the drugs or health care foods for prevention or/and treatment of low oxygen, hypoxia, hemic hypoxia, circulatory hypoxia and toxic hypoxia.

Description

Technical field [0001] The invention relates to a polysaccharide from the root of Daphne genkwa, in particular to the use of the polysaccharide from the root of Daphne genkwa in the preparation of anti-hypoxia drugs, and belongs to the field of medicinal natural products. Background technique [0002] Hypoxia is the most common stress factor in high altitude areas, aviation, diving and other special environments. People or animals that are acutely exposed to hypoxic environment will have hypoxic stress response. Appropriate stress response is beneficial for the body to adapt to various stimuli, maintain its own balance and internal environment stability, but excessive or long-term hypoxia stress will bring serious harm to the body. For example, excessive hypoxic stress can cause the body to appear exhausted after the alarm reaction occurs, through the adaptation and resistance stages. Under chronic hypoxic conditions, after the first alarm response of hypoxic stress subsides, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P39/00A61P43/00
Inventor 蒋思萍高平
Owner 西藏自治区高原生物研究所
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