Process for extracting active ingredients of traditional Chinese medicine in unit and combined type and device thereof

An extraction process and technology of active ingredients, applied in the field of modernization of traditional Chinese medicine, can solve problems such as unimaginable prognosis and unstable content of active ingredients.

Active Publication Date: 2009-09-16
王艺瑾
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] The serious problem facing the modernization of traditional Chinese medicine is that the content of active ingredients in domestic traditional Chinese medicine products is unstable, as Mr. Qiu Chenbo wrote in the book "Technology and Quality Control of Chinese Medicine Extraction Preparation" (Beijing: China Medical Science and Technology Press, 1995: 1), The content of active ingredients in the random sampling of commercially available Chinese patent medicines listed varies by several times, ten times or even dozens of times. The typical ones are the content of honokiol in Huoxiang Zhengqi Water and andrographolide in Compound Chuanxinlian Tablets. What is even more unimaginable is that Tanshinone II cannot be detected in Compound Danshen Tablets, the clinical first-choice drug for cardiovascular and cerebrovascular diseases... These technical problems have not been properly resolved

Method used

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  • Process for extracting active ingredients of traditional Chinese medicine in unit and combined type and device thereof

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Experimental program
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Effect test

specific Embodiment approach 1

[0023] Specific implementation plan 1: water osmotic distillation and high-efficiency azeotropic distillation series operation plan: open 2a and 2b quick-opening flanges of 1a and 1b stills, load Chinese medicinal materials, close 2a and 2b quick-opening flanges, Steam is introduced from the top of the 1a or 1b still, and the 1a or 1b still is connected in series from the bottom of the 1b or more 1a still to enter the bottom of the rectifying section of the 3 high-efficiency azeotropic distillation column, and the vapor phase enters the 4 top from the top of the tower The condenser enters the 5a and 5b oil-water separators through condensation, and the essential oil layer products are metered into the 6 essential oil tanks to obtain the volatile component products; the water in the water phase layer of the oil-water separator flows into the 7 return tanks, and passes through the 8 return pumps. Enter the top of the 3 high-efficiency azeotropic rectification tower and enter the ...

specific Embodiment approach 2

[0024] Specific implementation plan two: extractive distillation and high-efficiency azeotropic distillation series operation plan: open 2a and 2b quick-opening flanges of 1a and 1b stills, load Chinese medicinal materials, close 2a and 2b quick-opening flanges, from The bottom of 1a or 1b distillation tank is fed with steam, through 1a or 1b distillation tank in series, from the top of 1b or more 1a distillation tank, and enters the bottom of the rectification section of 3 high-efficiency azeotropic distillation tower, and the vapor phase enters 4 tower top from the top of the tower to condense After being condensed into the 5a and 5b oil-water separators, the essential oil layer products are metered into the 6 essential oil tanks to obtain volatile component products; the water in the water phase layer of the oil-water separator flows into the 7 reflux tanks, and through the 8 reflux pumps, into 3 The top of the high-efficiency azeotropic rectification tower enters the reflux...

specific Embodiment approach 3

[0025] Specific embodiment three: the semi-bionic method extraction scheme, put into the kettle body the raw material of traditional Chinese medicine through being pulverized into 80 mesh particle size, spray from the still top with the acidic water of PH3. Pour into the bed of Chinese medicinal materials, and at a temperature of 30-40°C, rotate the still for 0.5-1 hour to fully infiltrate the bed of Chinese medicinal materials with the acidic medium, then perform water osmotic distillation or extractive distillation for 1-3 hours, and then use distillation About 50% of the kettle volume, PH7.5-12.5 food-grade sodium bicarbonate alkaline water is sprayed from the top of the still into the bed of Chinese herbal medicines, and the still is rotated for 0.5-1 hour at a temperature of 30-40°C. Make the alkaline medium fully infiltrate the Chinese herbal medicine material bed, and then carry out extractive distillation connected in series with the azeotropic rectification tower for 1...

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Abstract

The invention belongs to highly effective extraction and separation of the active ingredients in field of modernization of Chinese medicine and is characterized in that on the basis of an extraction process and a device consisting of the combination of 3 novel chemical engineering unit operations of water percolation distillation, extractive distillation, and highly efficient az dist azeotropic distilation, the traditional and advanced techniques and devices for water distillation extraction, extraction by semi-bionic method, extraction by ultrasonic waves, extraction by enzyme process, extraction by microbial fermentation and extraction by microwave are preferably selected to constitute the unit and combined type extraction process and the device thereof; the process and the device of the invention is especially suitable for extracting the majority of single Chinese medicine or compound Chinese medicine with both volatile and non-volatile components; in addition the device operates stably with stable parameters; compared with the traditional multifunctional traditional Chinese medicine extracting tank, the tank of the invention features an extraction rate above 95% and energy conservation by over 50%, contraction of the production period by over 50%, reduction of production cost per unit product by 50% and stable content of active ingredients and product quality.

Description

technical field [0001] The invention belongs to the field of modernization of traditional Chinese medicine. The purpose of extracting the effective components of the traditional Chinese medicine is to extract the effective components in the medicinal materials to the greatest extent, avoid the decomposition and loss of the effective components, and extract the invalid or even harmful components to the maximum extent. The efficient extraction and separation of active ingredients in traditional Chinese medicine will surely become one of the most critical links in the modernization of traditional Chinese medicine. Background technique [0002] According to the data released by relevant departments, my country's traditional Chinese medicine industry continues to grow and develop. Up to now, there are nearly 1,500 Chinese medicine companies, and the industrial economic scale has exceeded 100 billion yuan; there are more than 9,000 varieties of Chinese patent medicines, and more th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/00B01D3/36B01D3/38B01D3/40A61K36/00
Inventor 王艺瑾王振锟
Owner 王艺瑾
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