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Application of 2'-O-beta-L-galactopyranosyl orientin and composition in preparing medicaments for resisting myocardial ischemia

A technology of galactoside and orientin, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems of lack of clear requirements and the like

Active Publication Date: 2009-10-21
JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yang Yaxin etc. have reported that Trollius chinensis extracts with 70% ethanol, extracts with n-butanol, and then separates with Sephadex LH-20 column to obtain orientin-2″-O-β-L-galactoside, orientin (Heilongjiang Medicine, 2006, 19(2), 93-94), but did not explicitly
So far, there is no literature report that orientin-2″-O-β-L-galactoside and its composition have anti-myocardial ischemia effect

Method used

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  • Application of 2'-O-beta-L-galactopyranosyl orientin and composition in preparing medicaments for resisting myocardial ischemia
  • Application of 2'-O-beta-L-galactopyranosyl orientin and composition in preparing medicaments for resisting myocardial ischemia
  • Application of 2'-O-beta-L-galactopyranosyl orientin and composition in preparing medicaments for resisting myocardial ischemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 Extraction and preparation of compositions containing orientin-2″-O-β-L-galactoside:

[0059] Trollius chinensis medicinal material was extracted 3 times with 50% ethanol under reflux, 2 hours each time. Filtrate, the filtrate is directly absorbed and purified through the AB-8 macroporous resin column, the ethanol is recovered from the effluent and 50% ethanol eluent until the alcohol content is less than 10%, and the concentrated solution is absorbed and purified through the AB-8 macroporous resin column. First wash with water, then elute with 50% ethanol, collect the 50% ethanol eluate, recover the solvent to dryness, heat and dissolve with 85% ethanol, add 1% medicinal active carbon, stir, filter, and the filtrate is directly purified through silica gel, And elute with 85% ethanol, collect the effluent and eluent, recover the solvent to dryness, and obtain a composition containing orientin-2″-O-β-L-galactoside. In this composition, orientin-2 The content...

Embodiment 2

[0060] Example 2 Extraction and preparation of compositions containing orientin-2″-O-β-L-galactoside:

[0061] Trollius chinensis medicinal material was extracted 3 times with 40% ethanol under reflux, 2 hours each time. Filtration, the filtrate is directly purified by adsorption on a polyamide column, the ethanol is recovered from the effluent and 40% ethanol eluent until the alcohol content is less than 10%, and the concentrated solution is purified by adsorption on an AB-8 macroporous resin column. Wash with water first, then elute with 50% ethanol, collect the 50% ethanol eluate, recover the solvent to dryness, heat and dissolve with 90% ethanol, add 1.5% medicinal active carbon, stir, filter, and the filtrate is directly purified through silica gel, And eluted with 90% ethanol, collected the effluent and eluate, recovered the solvent to dryness, and obtained a composition containing orientin-2″-O-β-L-galactoside. In this composition, orientin-2 The content of "-O-β-L-g...

Embodiment 3

[0062] Example 3 Preparation of orientin-2″-O-β-L-galactoside:

[0063] The composition containing orientin-2″-O-β-L-galactoside was separated and purified on a C-18 reverse-phase column (atmospheric pressure), and 20% aqueous acetonitrile was used as the eluent to collect orientin 2 The "-O-β-L-galactoside fractions were combined after TLC identification and recrystallized to obtain orientin-2"-O-β-L-galactoside crystals. The content was 98.5%.

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Abstract

The invention discloses novel application of composition with the content of flavone C-glycoside 2'-O-beta-L-galactopyranosyl orientin and 2'-O-beta-L-galactopyranosyl orientin between 30 and 90 percent in preparing medicaments for resisting angiocardiopathy such as myocardial ischemia and the like, and also describes a single component of the 2'-O-beta-L-galactopyranosyl orientin, a method for preparing the composition, and a medicinal preparation.

Description

technical field [0001] The present invention relates to orientin-2″-O-β-L-galactoside and its new medical application mainly containing orientin-2″-O-β-L-galactoside, specifically Orientin-2″-O-β-L-galactoside and compositions mainly containing orientin-2″-O-β-L-galactoside in the preparation of cardiovascular disease drugs caused by myocardial ischemia, etc. It also relates to the extraction, separation and pharmaceutical preparation of the drug, and the invention belongs to the technical field of medicine. Background technique [0002] Trollius, also known as "nasturtium", "dry land lotus", "golden hibiscus", "golden plum grass", "golden lump", etc., is the dried flower of Trollius chinensis Bge. of the Ranunculaceae plant. There are 25 species of Trollaceae plants, and the medicinal Trollius has wide petal trollia (Trollius asiaticus L.), short petal trollia (Trollius ledebouri Reichb.), and long petal trollia (TroUiusmacropetalus Fr.Schmidt). Nasturtium was first recor...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10A61K31/352C07H17/04C07H1/08
Inventor 赵全成南敏伦赫玉芳张瑜王婵
Owner JILIN MODERN TRADITIONAL CHINESE MEDICINE ENG RES CENT
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