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Traditional Chinese medicine extract composition for treating gastrointestinal dysfunction or irritable bowel syndrome, preparation method and application in preparation of medicine

A technology for irritable bowel syndrome and gastrointestinal dysfunction, which is used in the preparation of medicines for treating gastrointestinal dysfunction or anti-irritable bowel syndrome. Inconvenience, the effective substance of the compound is not completely clear and other problems, to achieve the effect of targeted production quality control, prominent drug effect, stable and controllable drug quality

Inactive Publication Date: 2012-02-15
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although Bupleurum, Radix Paeoniae Alba, Rhizoma Chuanxiong, Atractylodes Rhizome, Poria, Licorice and Radix Pseudostellariae have been clinically used to treat diseases such as intestinal dysfunction, functional dyspepsia, irritable bowel syndrome, etc. It is not completely clear, the preparation technology is not advanced, etc. In practical application, there are problems such as unstable clinical efficacy and inconvenience for patients to take.
These problems have seriously restricted the application effect of the compound

Method used

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  • Traditional Chinese medicine extract composition for treating gastrointestinal dysfunction or irritable bowel syndrome, preparation method and application in preparation of medicine
  • Traditional Chinese medicine extract composition for treating gastrointestinal dysfunction or irritable bowel syndrome, preparation method and application in preparation of medicine
  • Traditional Chinese medicine extract composition for treating gastrointestinal dysfunction or irritable bowel syndrome, preparation method and application in preparation of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] Embodiment 1. Preparation of the composition and its preparation for treating gastrointestinal dysfunction and irritable bowel syndrome of the present invention.

[0164] Expand the dose according to the following prescription proportions and take the medicine for later use: Bupleurum 9 grams, Radix Paeoniae Alba 9 grams, Atractylodes macrocephala 9 grams, Poria cocos 9 grams, licorice 6 grams, Radix Pseudostellariae 6 grams, Rhizoma Chuanxiong 6 grams. Take Atractylodes macrocephala and crush it into coarse powder, add 8 times the amount of water to soak for 3 hours, steam distill to extract the volatile oil for 6 hours, collect the volatile oil, filter the medicinal solution, and set aside. Other medicinal materials in the prescription were soaked in water for 4 hours, combined with Atractylodes macrocephala residue after extracting volatile oil, extracted twice, each time for 1.5 hours, 10 times of water, combined medicinal solution, concentrated to a relative density...

Embodiment 2

[0165] Example 2. Preparation of the composition for treating irritable bowel syndrome of the present invention and its preparation.

[0166]Expand the dosage according to the following prescription proportions and take the medicine for later use: Bupleurum 12 grams, Radix Paeoniae Alba 12 grams, Atractylodes macrocephala 12 grams, Poria cocos 12 grams, licorice 6 grams, Radix Pseudostellariae 6 grams, Rhizoma Chuanxiong 6 grams. Take Atractylodes macrocephala and crush it into coarse powder, add 8 times the amount of water to soak for 3 hours, steam distill to extract the volatile oil for 6 hours, collect the volatile oil, filter the medicinal solution, and set aside. Soak the other medicinal materials in the stated proportion with water for 4 hours, combine with the Atractylodes macrocephala residue after extracting the volatile oil, decoct and extract twice, each time for 1.5 hours, 10 times the water, combine the medicinal liquid, filter, and concentrate to contain 0.4g of ...

Embodiment 3

[0167] Example 3 Preparation of the composition for treating irritable bowel syndrome and its preparation of the present invention.

[0168] Expand the dosage according to the following prescription proportions and take the medicine for later use: Bupleurum 12 grams, Radix Paeoniae Alba 12 grams, Atractylodes macrocephala 12 grams, Poria cocos 12 grams, licorice 6 grams, Radix Pseudostellariae 6 grams, Rhizoma Chuanxiong 6 grams. Take Atractylodes macrocephala and crush it into coarse powder, add 8 times the amount of water to soak for 3 hours, extract the volatile oil for 6 hours, collect the volatile oil, filter the medicinal solution, and set aside. Other medicinal materials in the prescription are soaked in water for 4 hours, combined with Atractylodes macrocephala residues after extracting volatile oil, extracted twice, each time for 1.5 hours, 10 times of water, combined extracts, filtered, concentrated to 0.1g crude drug per ml, centrifuged, and taken Supernatant, treat...

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Abstract

A traditional Chinese medicine extract composition for treating gastrointestinal dysfunction or irritable bowel syndrome, a preparation method and its application in the preparation of medicines. Composition of raw materials: Bupleurum 9-12 grams, Radix Paeoniae Alba 9-12 grams, Atractylodes macrocephala 9-12 grams, Poria cocos 9-12 grams, licorice 3-6 grams, Radix Pseudostellariae 3-6 grams, Rhizoma Chuanxiong 3-6 grams; Extracts of raw materials are used for each component, among which, the volatile oil of Atractylodes macrocephala becomes component 1; the concentrated extract of Atractylodes macrocephala dregs after extracting volatile oil and the water decoction of other medicinal materials becomes component 2; appropriate amount of cyclodextrin becomes component 3 . The invention overcomes the traditional viewpoint that "the effect of the total extract or water decoction of the crude drug of traditional Chinese medicine is better than that of the partial extract", and selectively uses the volatile oil in the crude drug. The combined treatment can also significantly improve the preparation performance of the extract and ensure the quality of the composition. The composition for treating gastrointestinal dysfunction or irritable bowel syndrome of the present invention uses the extract to produce unexpected effects.

Description

technical field [0001] The present invention relates to a composition (Chinese medicine compound extract) for treating gastrointestinal dysfunction or irritable bowel syndrome (IBS), and a preparation method of the composition for treating gastrointestinal dysfunction or irritable bowel syndrome; and Application of the composition for treating gastrointestinal dysfunction or irritable bowel syndrome in the preparation of medicaments for treating gastrointestinal dysfunction or anti-irritable bowel syndrome. Background technique [0002] Gastrointestinal dysfunction is a common clinical functional intestinal disease, accounting for about 40-60% of gastrointestinal diseases. Among them, irritable bowel syndrome (irritable bowel syndrome, IBS) is a common non-organic intestinal dysfunction disease of the digestive tract, which has the clinical characteristics of chronic recurrent attacks. The prevalence in adults is 10% to 22%, and it is slightly more common in women. Its mai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00
Inventor 杨星昊费方利陈晨苏淮
Owner NANJING NORMAL UNIVERSITY
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