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Complex preparation of stephanotis and antibiotic for treating infectious disease

A technology of infectious diseases and compound preparations, which is applied in the field of compound preparations of Baiyaozi and antibiotics, can solve the problems of enhancing the sensitivity of drug-resistant bacteria, and achieve the goals of solving the problem of bacterial drug resistance, inhibiting drug resistance, and enhancing antibacterial activity in vitro Effect

Inactive Publication Date: 2011-11-09
王教玉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of Baiyaozi in enhancing the susceptibility of drug-resistant bacteria has not been reported

Method used

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  • Complex preparation of stephanotis and antibiotic for treating infectious disease
  • Complex preparation of stephanotis and antibiotic for treating infectious disease
  • Complex preparation of stephanotis and antibiotic for treating infectious disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 100 g of Baiyaozi decoction pieces, powder it into a fine powder in a Soxhlet extractor, extract with 70% ethanol under reflux for 4 hours, recover ethanol, and obtain 0.7 g of Baiyaozi extract.

Embodiment 2

[0019] Under GMP conditions, take Baiyaozi extract and cephalexin respectively according to their content conversion, and prepare according to the tablet / capsule production standard with the ratio of Baiyaozi extract and cephalexin anhydrous as 8:1 (weight ratio) into Baiyaozi extract / cephalexin tablet or capsule.

Embodiment 3

[0021] Under GMP conditions, take Baiyaozi extract and oxacillin sodium respectively according to their content conversion, and use Baiyaozi extract and oxacillin sodium anhydrous as 8:1 (weight ratio) according to aseptic operation According to the technical specifications, mix evenly in the mixer, calculate the average loading, put it into sterilized glass bottles in the ultra-clean workbench (partial 100 grade), put on the plug, press the cap, and label to obtain the Baiyaozi compound / Antibiotic powder injection.

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Abstract

The invention relates to a traditional Chinese medicine which solves the problem of medicine resistance by being in compatibility with antibiotic i.e. a complex preparation of stephanotis and the antibiotic for treating infectious diseases. The complex preparation is prepared by mixing stephanotis extract and the antibiotic according to a specified proportion, and the complex preparation can inhibit medicine resistance, obviously strengthen in vitro antibacterial activity and animal in vivo anti-infection effect of the antibiotic, can obviously enlarge an antibacterial spectrum of the antibiotic, expand a clinical application range thereof, efficiently solve the problem of bacterial medicine resistance and strengthen the clinical effect thereof.

Description

technical field [0001] The invention relates to a combination of traditional Chinese medicinal plants and antibiotics to solve the problem of drug resistance, that is, a compound preparation of Baiyaozi and antibiotics for treating infectious diseases. Background technique [0002] Since the advent of penicillin, the world's first antibiotic, antibiotics have effectively controlled infectious diseases. However, with the widespread use of antibiotics, bacterial drug resistance has become a difficult problem in the treatment of infectious diseases, resulting in prolonged treatment courses, increased medical expenses, and increasingly shortened effective cycles of newly marketed antibiotics, and increased the incidence and death of infectious diseases. rate increased. The main reason for the increase in the fatality rate is the difficulty in medication brought by drug-resistant bacteria. Developing new antibiotics is a traditional method to prevent and treat drug-resistant ba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/59A61K45/00A61P31/00
Inventor 付为金
Owner 王教玉
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