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Novel medicinal composition for relieving cough

A composition and pharmacy technology, which can be used in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve problems such as death and adverse reactions.

Active Publication Date: 2010-06-16
YICHANG HUMANWELL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dextromethorphan is safe and effective in suppressing cold symptoms when used correctly in small doses, but overuse can cause death and other serious adverse effects such as brain damage, seizures, loss of consciousness and irregular heartbeats, the U.S. Food and Drug Administration said.

Method used

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  • Novel medicinal composition for relieving cough
  • Novel medicinal composition for relieving cough
  • Novel medicinal composition for relieving cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Phalcodine, guaiacol glycerol ether and chlorpheniramine maleate syrup

[0045]

[0046] Preparation:

[0047] In the 100,000 class clean area

[0048] A540g of sucrose is dissolved in 200ml of boiled water to make a syrup and filtered;

[0049] B. Weigh 0.1g of Folcodine and dissolve it in an appropriate amount of ethanol;

[0050] C Weigh 0.1 g of chlorpheniramine maleate and 4.0 g of guaifenesin in 50 mL of purified water;

[0051] D. Mix the solution obtained from step A, step B and step C, add purified water to 1000 mL, filter to obtain syrup, check it, and dispense it.

Embodiment 2

[0052] Example 2: Phalcodine, guaiacol glycerol ether and chlorpheniramine maleate oral liquid

[0053]

[0054] Preparation:

[0055] In the 100,000 class clean area

[0056] A. Weigh 0.1g of Folcodine and dissolve it in an appropriate amount of ethanol;

[0057] B Weigh 0.1 g of chlorpheniramine maleate and 4.0 g of guaiacol glycerol ether in 50 mL of purified water;

[0058] C. Mix the solution obtained in step A and step B, add citric acid, sodium citrate, correctives, potassium sorbate, EDTA-2Na dissolved purified water to 1000mL, filter, check, aliquot, sterilize, that is can.

Embodiment 3

[0059] Example 3: Phalcodine, guaiacol glycerol ether and chlorpheniramine maleate granules

[0060]

[0061] Preparation:

[0062] Class 100,000 clean area

[0063] A Pholcodine, guaiacol glycerol ether, chlorpheniramine maleate, citric acid, starch, sucrose powder pass 100# sieve;

[0064] B. Weigh the prescribed amount of Pholcodine, Guaifenesin, Chlorpheniramine Maleate, Citrate, Starch, Sucrose Powder, and appropriate amount of correctives, and mix them evenly;

[0065] C Weigh a certain amount of HPMC, mix it with a 50% ethanol solution to a concentration of 2%, and dissolve the essence in the HPMC solution;

[0066] D made soft material, passed through 18# sieve, dried at 50℃, controlled moisture 1.8%, 16# sieve, granulated.

[0067] E is divided into bags and packed.

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PUM

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Abstract

The invention discloses a medicinal composition capable of relieving cough and reducing sputum and a production method thereof. The composition is especially used for treating cough symptoms in the diseases of the respiratory system, such as influenza, whooping cough, bronchitis, laryngitis and the like. A medicine prepared from the composition comprises the following effective components in unit dose: 0.01-20mg of pholcodine, 0.1-300mg of guaiphenesin and 0.01-20mg of maleic acid / or hydrochloride chlorpheniramine. The medicinal composition is an oral preparation. Compared with the similar medicine, the medicinal composition has the characteristics of small dosage, favorable curative effect, high safety and convenient taking.

Description

Technical field [0001] The present invention relates to a medicinal composition, and more specifically, to a medicinal composition with phalcodine, guaiacol glycerol ether and chlorpheniramine or a pharmaceutically acceptable salt thereof as active ingredients, and production method. Background technique [0002] Cough and expectoration are two common symptoms of respiratory system diseases, which are closely related in pathology. Generally, every cough that contains more sputum, and more sputum often causes cough. Long-term failure to heal may cause emphysema, bronchiectasis, pulmonary heart disease, etc. . [0003] At present, the commonly used antitussive drugs in pharmaceutical drugs include codeine phosphate, dextromethorphan hydrobromide, and folcodine. [0004] Codeine phosphate is a central neurochemical drug widely used to relieve coughs or colds, but in recent years it has been repeatedly raised by the National Food and Drug Administration due to its serious adverse react...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61K31/09A61K31/4402A61P11/14A61P11/10A61P31/16A61P11/04
Inventor 符义刚朱卫国何平平李莉娥
Owner YICHANG HUMANWELL PHARMA
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