Method for amplifying lymphocyte by interleukin 15 receptor and interleukin 2 complex

A technology of lymphocytes and interleukins, applied in the field of immunology, can solve problems such as inability to enhance innate immunity and stress immunity, and achieve the effect of improving immunity and resisting viruses and bacteria
CN101735982AInactive Publication Date: 2010-06-16浙江中赢控股集团有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
浙江中赢控股集团有限公司
Publication Date
2010-06-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a technology in the aspect of immunology, in particular to a method for amplifying natural killer (NK) cells and CD8 lymphocyte by interleukin 2 and interleukin 15 receptor (IgG1 Fc) and interleukin 2 complex. A polypeptide complex is cultured by an interleukin 2 and the interleukin 15 receptor which are protein having the expression function, and the aim of changing the immune state is achieved by the lymphocyte or a lymphocyte precursor cell activated and amplified by the polypeptide complex. The patient is helped to resist a tumour, viruses and bacteria by improving the immunity through the interleukin 15 receptor (IgG1 Fc) and interleukin 2 complex, and the realizing effect is good. The invention has wide prospect in the aspect of immunology.
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Description

technical field

[0001] The invention belongs to the field of immunology, specifically refers to the use of interleukin 2, interleukin 15 receptor (IgG1 Fc)-interleukin 2 complex to expand natural killer cells (NK) and CD8 lymphocytes. technical background

[0002] Previous studies have shown that interleukin 2 and interleukin 15 are involved in the activation process of innate immunity and acquired adaptive immunity of NK cells, dendritic cells and CD8 cells. However, previous efforts to expand these cells with interleukin-15 or interleukin-2 in vitro and in vivo have been limited.

[0003] Interleukin 15 and interleukin 2 activate CD8 and NK cells by binding to specific receptors on the surface of CD8 and NK lymphocytes. Interleukin 2, interleukin 15 and interleukin 15 receptor are strongly expressed in activated dendritic cells and monocytes. Interleukin 2 and interleukin 15 can respectively bind to interleukin 15 receptors to form heterodimer complexes to activate CD8 a...

Claims

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