Milkvetch root extract, preparation method and application thereof

An extract of astragalus and technology of astragalus, applied in the field of traditional Chinese medicine, can solve the problems of no breakthrough in treatment, aggravation of HAAF, and rising incidence of hypoglycemia, achieve good treatment prospects, and improve the effect of early warning mechanism

Inactive Publication Date: 2010-07-21
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existence of HAAF significantly increases the incidence of hypoglycemia in patients, and repeated hypoglycemia will further aggravate the degree of HAAF, so it will often fall into a vicious circle, seriously affecting the blood sugar control of patients
[0004] At present, several famous endocrinology laboratories abroad, led by Yale University, are actively exploring the mechanism and countermeasures of HAAF, but there is no breakthrough in treatment.

Method used

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  • Milkvetch root extract, preparation method and application thereof
  • Milkvetch root extract, preparation method and application thereof
  • Milkvetch root extract, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 2000g of the original medicinal material of Radix Astragali, add water and decoct three times, 1.5 hours each time, combine the decoction, filter, and concentrate the filtrate to 1g of the original medicinal material per 1ml, and use ethanol precipitation for two times. The ethanol content in the first solution is 75% and 85% for the second time, each time it was placed in cold storage for 12 hours, recovered ethanol and concentrated to 10 g of the original medicinal material per 1 ml, diluted with water for injection to 0.75 g of the original medicinal material per 1 ml, and placed in cold storage for 12 hours. Filter, concentrate the filtrate to 5g of the original medicinal material per 1ml, let it cool, adjust the pH value to 7.5 with 20% sodium hydroxide solution, boil, add 0.125% activated carbon, boil for 5 minutes, filter while it is hot, add water for injection Make it into 1000ml, filter it, adjust the pH value to 6.0-7.5 with 20% sodium hydroxide solution,...

Embodiment 2

[0032] Take 2000g of the original medicinal material of Astragalus membranaceus, add water and decoct three times, 1.5 hours each time, combine the decoction, filter, and concentrate the filtrate to 2g of the original medicinal material per 1ml, and use ethanol precipitation for two times. The ethanol content in the first solution is 75% and 85% for the second time, each time it was placed in cold storage for 12 hours, recovered ethanol and concentrated to 10 g of the original medicinal material per 1 ml, diluted with water for injection to 1 g of the original medicinal material per 1 ml, placed in cold storage for 12 hours, filtered After filtration, the filtrate was concentrated to 6g of the original medicinal material per 1ml, let it cool, adjusted the pH value to 7.5 with 20% sodium hydroxide solution, boiled, added 0.125% activated carbon, boiled for 5 minutes, filtered while it was hot, and added water for injection. into 1000ml, filter, and then adjust the pH value to 6....

Embodiment 3

[0034] Take 2000g of the original medicinal material of Astragalus membranaceus, add water and decoct three times, 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to 1.5g of the original medicinal material per 1ml, and use ethanol precipitation treatment twice, the ethanol content in the solution for the first time 75% for the second time, 85% for the second time, each time refrigerated for 12 hours, recovered ethanol and concentrated to 10g of the original medicinal material per 1ml, diluted with water for injection to 0.9g of the original medicinal material per 1ml, and refrigerated for 12 hours , filter, the filtrate is concentrated to 5.5g of the original medicinal material per 1ml, let it cool, adjust the pH value to 7.5 with 20% sodium hydroxide solution, boil, add 0.125% activated carbon, boil for 5 minutes, filter while hot, add Make 1000ml of water for injection, filter, then adjust the pH value to 6.0-7.5 with 20% sodium hydroxide solution...

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Abstract

The invention discloses a milkvetch root extract. The milkvetch root extract contains astragaloside IV the content of which is no less than 0.08mg / ml; the invention also provides a preparation method of the milkvetch root extract, which extracts the active constituent of astragalus membranaceus by a water ethanol method; and in addition, the invention also provides an application of the milkvetch root extract in preparing medicaments which prevent and control diabetics from damage caused by retroegulation of hypoglycemia hormone. Animal experiments indicate that: the active constituent of the astragalus membranaceus in the invention has the function of reconstructing part of hormone reactions of HAAF rat model, can activate sugar-sensitive parts such as PVN, NTS and the like and CRF nerve-corpuscle in a brain, thereby improving the early warning mechanism of an organism to hypoglycemia. The invention has a wide prospect of curing one of the complications of diabetes mellitus, i.e. HAAF.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to an astragalus extract; in addition, the invention also relates to a preparation method and application of the astragalus extract. Background technique [0002] One of the complications of diabetes, HAAF, is an important obstacle for diabetics to obtain close to normal blood sugar control. Data show that intensive insulin therapy to reduce long-term complications of type 1 diabetes nearly tripled the incidence of hypoglycemia. The main mechanism of HAAF is that recurrent hypoglycemia greatly weakens the emergency regulation of hypoglycemia by adrenaline, glucagon and other counter-regulatory hormones, making the sympathetic-adrenal system significantly slow in responding to hypoglycemia, and the nervous system responds to hypoglycemia. The sensitivity to hypoglycemia decreases, and patients themselves often lack awareness of hypoglycemia symptoms, especially during sleep....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P3/10
Inventor 桑珍周里钢范晓宁
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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