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Application of gallic acid in preparation of phosphodiesterase inhibitor anti inflammatory medicine

A gallic acid, preparative technology, applied in the separation/purification of carboxylic acid compounds, anti-inflammatory agents, drug combinations, etc., can solve the problems of scarce sources, unclear, limited curative effect of rat colitis, etc., and achieve good therapeutic prospects , clear mechanism, less toxic and side effects

Inactive Publication Date: 2013-11-06
BEIJING UNIV OF AGRI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effective part of the anti-inflammatory effect in this patent application is a combination of various compounds such as gallic acid and meta-digallic acid. The mechanism of action is not yet clear; moreover, the effective part is only extracted from the gallic medicinal material, the source is scarce, and the curative effect on colitis in rats is limited

Method used

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  • Application of gallic acid in preparation of phosphodiesterase inhibitor anti inflammatory medicine
  • Application of gallic acid in preparation of phosphodiesterase inhibitor anti inflammatory medicine
  • Application of gallic acid in preparation of phosphodiesterase inhibitor anti inflammatory medicine

Examples

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Effect test

Embodiment 1

[0033] This example provides the application of gallic acid in the preparation of phosphodiesterase inhibitor anti-inflammatory drugs.

[0034] The anti-inflammatory drug contains gallic acid, and the weight of gallic acid accounts for 0.04×10 of the total weight of the anti-inflammatory drug. -3 —3×10 -3 .

[0035] In this embodiment, an anti-inflammatory drug containing a single component of gallic acid can be prepared.

[0036] This embodiment can also prepare an anti-inflammatory pharmaceutical composition containing gallic acid. The anti-inflammatory pharmaceutical composition can be one or more natural or chemically synthesized active components, or one or more Chinese medicinal materials or their Anti-inflammatory pharmaceutical composition composed of active ingredient and gallic acid.

[0037] When preparing the anti-inflammatory drug in this example, it is safe to take it orally or parenterally. When administered orally, the anti-inflammatory drug can be in any c...

Embodiment 2

[0054] This example is the application of gallic acid optimized on the basis of Example 1 in the preparation of phosphodiesterase inhibitor anti-inflammatory drugs.

[0055] The dosage form of the anti-inflammatory drug in this embodiment is an injection prepared from gallic acid and normal saline, and the concentration of the gallic acid is 0.04-3 mg / ml.

[0056] The unit of weight used in this embodiment is kilogram, and may also be gram.

[0057] The injection method of the anti-inflammatory drug is: intramuscular injection, daily injection of 10-20ml;

[0058] The gallic acid in the anti-inflammatory drug is extracted from Radix Paeoniae Alba;

[0059] The preparation method of described anti-inflammatory drug is:

[0060] Ⅰ. Preparation of Radix Paeoniae Alba Extract:

[0061] A. The decoction pieces of Radix Paeoniae Alba are subjected to rinsing treatment, decocting treatment for 2 times in sequence, and the decoctions of the decoction treatment for 2 times are combi...

Embodiment 3

[0076] This example is a preferred scheme based on Example 2. The quality of the raw materials (components) used is the same as that of Example 2. The anti-inflammatory drug is prepared from gallic acid and normal saline, and the gallic acid The concentration is 0.04 mg / ml.

[0077] The unit of weight used in this embodiment is kilogram, and may also be gram.

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Abstract

The invention provides application of gallic acid to preparation of a phosphodiesterase inhibitor anti inflammatory medicine. The anti inflammatory medicine comprises gallic acid which accounts for 0.004 to 0.3 percent of the total weight of the anti inflammatory medicine. The formulation of the anti inflammatory medicine is injection which is prepared from gallic acid and normal saline; and the concentration of the gallic acid is 0.04 to 3mg / ml. In the application of the gallic acid to the phosphodiesterase inhibitor anti inflammatory medicine, the gallic acid is separated from a Chinese medicine, namely white paeony root, and the source of the gallic acid is common, and the anti inflammatory medicine has an accurate mechanism, small toxic and side effects and good treatment prospect.

Description

technical field [0001] The invention belongs to the application field of gallic acid in pharmacy, and in particular relates to a method for extracting gallic acid. Background technique [0002] Phosphodiesterase (PDE) is a specific hydrolase of cyclic AMP cAMP, mainly distributed in inflammatory cells, especially neutrophils. PDE inhibitors can inhibit the activity of PDE, increase the level of cAMP, enhance the activity of protein kinase A, inhibit the activation of reduced coenzyme II (NADPH) oxidase, thereby inhibiting the respiratory burst, and regulating the excessive activation of inflammatory cells such as neutrophils. The inflammatory response of inflammatory response is of great significance to the treatment of inflammatory diseases. Therefore, PDE4 inhibitors, as a new type of anti-inflammatory drugs, have become the focus of current research. Currently commonly used PDE inhibitors are chemically synthesized drugs, such as Rolipram, Piclamilast, Cilomilast, and R...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61P29/00A61P27/16A61P19/02C07C65/03C07C51/42
Inventor 陈武姜代勋陈益山董虹
Owner BEIJING UNIV OF AGRI
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