System and method for dispensing fluids
A fluid and holder technology, applied in chemical instruments and methods, support of flat carriers, analysis materials, etc., can solve problems such as pipetting operations, increasing cross-contamination of samples, increasing errors, etc.
Inactive Publication Date: 2010-12-01
F HOFFMANN LA ROCHE & CO AG
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- Description
- Claims
- Application Information
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Problems solved by technology
While such differences may not be considered critical in the case of multi-slot well plates with a relatively low number of wells, in the case of multi-slot well plates with large arrays, due to the distance between adjacent wells, Often smaller distances, problems with pipetting can arise
Non-homogeneous plates may, for example, suffer from unintentional contact between pipettes and wells, which may be accompanied by increased risk of sample cross-contamination
Additionally, increased errors in pipetting operations can occur
Method used
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[0096] Specific exemplary embodiments in which the invention may be practiced are described, by way of illustration. In this regard, terms relating to orientation and direction, such as "horizontal", "vertical", "upper", "lower", "middle" are used with reference to the orientation of the drawings being described. Because components of the described embodiments may be positioned in many different orientations, this terminology is used for purposes of illustration only and not in any way of limitation.
[0097]Thus, the system 1 for dispensing fluids comprises a holder 2 for holding a target multi-slot well plate 3 in a predefined holding position. The holder 2 consists of a plate bracket 4 for holding a target multi-slot well plate 3 supported by a substructure 5 supporting the plate bracket 4 . The substructure 5 consists of several sections mounted on each other. Specifically, the substructure 5 comprises: a lower part 6 having a rectangular base plate 7 provided with four ...
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The invention provides a system and method for dispensing fluids. The present invention pertains to a system for dispensing one or more fluids into wells of a target multi-well plate, comprising a holder for holding said multi-well plate in a predefined holding position, said plate having a well region provided with plural wells for accommodating said fluids and an edge region surrounding said well region, said holder including: a contact area adapted to contact said edge region for forming a sealing zone air-tightly sealing a void formed between said holder and said plate; at least one supporting face adapted to support said well region in a planar condition; a duct for connection to a pump for generating a negative pressure in said void so as to draw said well region onto said at least one supporting face. It further relates to such holder. It yet further relates to a method for dispensing fluids into wells of a target multi-well plate, comprising the following steps of: providing such holder and a multi-well plate in holding position and generating a negative pressure in said void so as to pull said well region onto said at least one supporting face.
Description
technical field [0001] The present invention relates to systems and methods for automatically dispensing fluid into wells of a targeted multi-well well plate. Background technique [0002] In view of the continued increase in the clinical analysis of bodily fluids, many efforts have been made to develop new automated pipetting instruments that enable multiple pipetting operations to be performed in parallel, often involving the use of multi-well well plates. A multi-slot well plate provides a plurality of wells for receiving fluid, which are regularly arranged in a two-dimensional array consisting of columns and rows crossing each other at right angles. Intended for single use only, multi-slot well plates made of plastic are industrially produced in large numbers within the limits of certain flatness tolerances, so that they may present a slightly convex or concave upper face. While such differences may not be considered critical in the case of multi-slot well plates with a...
Claims
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IPC IPC(8): G01N35/10
CPCB01L2300/0829G01N35/1065B01L9/52B01L9/523G01N35/1083
Inventor C·彻鲁比尼M·科普E·萨罗菲姆
Owner F HOFFMANN LA ROCHE & CO AG