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Method for improved scaling of filters

A technology for scaling and filtering equipment, applied in the direction of chemical instruments and methods, instruments, membranes, etc., which can solve problems such as acceptable performance tolerances

Active Publication Date: 2011-03-30
MILLIPORE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as in any production method, there is a finite tolerance in acceptable performance from one batch of membrane to another

Method used

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  • Method for improved scaling of filters
  • Method for improved scaling of filters
  • Method for improved scaling of filters

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A key performance parameter for sterile gradient membrane filters is water permeability, which correlates with the productivity of the device. Water permeability is measured by supplying water to a membrane, maintaining a pressure differential across the membrane, and measuring the water flow velocity. Permeability was calculated according to the following formula:

[0025] Lp=Q / (A*ΔP)

[0026] where Lp is the water permeability, A is the membrane area, and ΔP is the pressure difference across the membrane. Water permeability is usually in unit L / (m 2 -hr-psi) or LMH / psi.

[0027] Water permeability was measured on a representative set of pleated boxes, each containing approximately 0.5m2 A polyethersulfone membrane with a nominal pore size of 0.2 μm. Figure 5 Distribution curves are shown. Water permeability is from about 1000 LMH / psi to about 1300 LMH / psi. A subset of the membranes contained in the entire population were selected for installation into a small s...

Embodiment 2

[0029] Based on the water permeability distribution of Example 1, a single membrane that had been characterized for water permeability was selected from the entire membrane population. Since the water permeability of the membrane is known, Equation 2 can be applied and the scale factor uncertainty ratio is 1300 / 1000 = 1.3, representing a 23% improvement in scale factor uncertainty compared to the prior art.

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Abstract

The present invention relates to a method for improved scaling of filters, further to a method of reducing performance variability of membrane scaling devices. Scaling device performance uncertainty is reduced, thereby reducing the scaling safety factor, by specifying a narrow range or subset of the set of all qualified manufactured membranes for installation into scaling devices. In certain embodiments, the scalability factor is reduced by determining where within the performance distribution a particular membrane lies, and adjusting the scaling factor accordingly.

Description

[0001] This application claims priority to US Provisional Application No. 61 / 274142, filed August 13, 2009, the disclosure of which is incorporated by reference. technical field [0002] The present invention relates to a method of improving filter scaling. Background technique [0003] Manufacturers of filtration equipment typically provide small scale sizing tools for initial evaluation of process streams and for estimating membrane area requirements for full scale processes. Ideally, small-scale devices should contain minimal membrane area or filter media to conserve test fluid while also scaling linearly with their corresponding large-scale devices. However, variability in small-scale device performance adds uncertainty to the scale-up requirement, leading to potentially excessive sizing to avoid the possibility that the small-scale device tested represents the low end of the performance distribution. [0004] For example, with microfiltration membrane filters, there ar...

Claims

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Application Information

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IPC IPC(8): B01D61/00B01D65/10
CPCB01D65/10B01D2325/20G01N15/0826B01D69/02Y10T29/4978Y10T29/49604Y10T29/496
Inventor S·吉利亚M·布兰查德K·劳蒂奥
Owner MILLIPORE CORP