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Medicament for treating breast cancer and preparation method thereof

A breast cancer and drug technology, applied in the field of medicine, can solve problems such as no data showing curative effect and significant

Inactive Publication Date: 2011-09-28
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment methods for breast cancer are drugs and surgery. Most patients need surgical treatment. Chemotherapy after surgical resection of the tumor is a better treatment method. Regardless of drug treatment or drugs taken during chemotherapy after surgery, effective drugs are generally Both are western medicines, however, the side effects of western medicines have been clinically proven to be very obvious
Although there are traditional Chinese medicines for treating breast cancer in the published data, there is no data showing that their curative effect is significant

Method used

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  • Medicament for treating breast cancer and preparation method thereof
  • Medicament for treating breast cancer and preparation method thereof
  • Medicament for treating breast cancer and preparation method thereof

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Effect test

Embodiment

[0047] The medicine of the present invention is made into a medicament by the active ingredients of the medicine and pharmaceutical excipients, and the structural formula of the active ingredients of the medicine is 3β-hydroxyl-28-norursoh-12,17-dien-22-one

[0048]

[0049] The active ingredient of the medicine is 1%-90% by weight percentage, and the pharmaceutical auxiliary material is 10%-99%. The medicine of the present invention can be made into various dosage forms, such as: injections: aqueous injections, freeze-dried powders, tablets, capsules, Granules, powder or oral liquid.

[0050] The dosage form of the medicine is a tablet, and the active ingredient of the tablet is 20%-70%, and the pharmaceutical auxiliary material is 30%-80%.

[0051] The dosage form of the medicament is a capsule, and the active ingredient of the medicine in the capsule is 20%-90%, and the pharmaceutical auxiliary material is 10%-80%.

[0052] The dosage form of the medicine is water injec...

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Abstract

The invention discloses a medicament for treating breast cancer and a preparation method thereof. The medicament comprises medicament effective components which are 3beta-hydroxyl-28- norursol-12 and 17-diene-22-ketone and a medicament which is prepared from a medicinal auxiliary material, wherein the medicament effective components are 1-90 percent by weight, and the medicinal auxiliary materialis 10-99 percent. The structural formula of the medicament effective components is shown in the specification. The preparation method comprises the following steps of: (1) pulverizing garden burnet carbon as a medicament raw material, adding carbinol or ethanol, extracting and filtering and concentrating filter liquor to obtain fluid extract; (2) dispersing the fluid extract in the step (1) by water, extracting by chloroform and recovering a solvent of extract liquor to obtain extract; (3) carrying out silica gel column chromatography separation on the extract in the step (2) and sucking and filtering the obtained solid and recrystallizing to obtain the medicament effective components of the compound; and (4) taking the medicament effective components according to the weight proportion and retaining the medicinal auxiliary material for preparing the medicament. The invention has good treatment effect on treating breast cancer and can replace western medicines for oral administration in the postoperative chemotherapy period.

Description

technical field [0001] The invention relates to medicine, which is a medicine for treating breast cancer and a preparation method thereof. Background technique [0002] Breast cancer is a disease with a high incidence rate. According to preliminary statistics, the incidence rate has gradually increased in the past 10 years. The current treatment methods for breast cancer are drugs and surgery. Most patients need surgical treatment. Chemotherapy after surgical resection of the tumor is a better treatment method. Regardless of drug treatment or drugs taken during chemotherapy after surgery, effective drugs are generally All are western medicines, but the side effects of western medicines are clinically proven to be very obvious. Although there are traditional Chinese medicines for treating breast cancer in the published data, there is no data showing that their curative effect is significant. Therefore, in order to reduce the toxic and side effects of breast cancer patients ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P35/00C07J63/00
Inventor 孙立立杨书斌施祖荣周倩夏红旻石典花
Owner SHANDONG ACAD OF CHINESE MEDICINE
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