Ginkgolides K and compound thereof as well as preparation method and use thereof

A technology of ginkgolide and compound, which is applied to the field of ginkgolide and its compound, and achieves the effects of reducing the degree of nuclear dissolution and reducing the softening focus

Active Publication Date: 2013-07-17
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no ginkgolide K preparation on the market at home and abroad

Method used

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  • Ginkgolides K and compound thereof as well as preparation method and use thereof
  • Ginkgolides K and compound thereof as well as preparation method and use thereof
  • Ginkgolides K and compound thereof as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1. A preparation method of ginkgolide K, the steps of which are as follows: adding ginkgolide B in an alkaline aqueous solution, heating and dissolving in a water bath, and keeping the temperature; after detecting that the ginkgolide B is basically converted completely, then adjusting the pH value with an acidic aqueous solution When the solution becomes acidic, it is left to stand, filtered to obtain a precipitate, the precipitate is taken and washed with water, then dissolved in an organic solvent, concentrated, and recrystallized to a purity of more than 90%.

Embodiment 2

[0086] Example 2. A preparation method of ginkgolide K, the steps of which are as follows: adding a ginkgolide extract containing ginkgolide B to a mixed solution of alkaline water and alcohol, heating and dissolving in a water bath, and keeping warm; After the transformation is complete, then adjust the pH value with an acidic aqueous solution until the solution is acidic, stand, centrifuge to obtain a precipitate, take the precipitate and add water to wash, then dissolve in an organic solvent, concentrate, and recrystallize to a purity of more than 90%.

Embodiment 3

[0087] Example 3. A preparation method of ginkgolide K, the steps of which are as follows: adding ginkgolide B in a mixed solution of water and alcohol, heating and dissolving in a water bath, and keeping warm; The crystals are then dissolved in an organic solvent, concentrated, and recrystallized until the purity reaches more than 90%.

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Abstract

The invention discloses a compound of ginkgolides K of which a general formula is shown in (I), and a composition is prepared by mixing the ginkgolides K compound and pharmaceutically-acceptable medicine carrier, wherein G is alkaline substances. The invention also discloses a preparation method of the compound and treatment use thereof. In the invention, the ginkgolides K compound changes the physical property of the ginkgolides K, thereby the invention has the advantages of good stability, and the ginkgolides K compound has good water-solubility and higher stability. In the compound, a natural structure of the ginkgolides K can be kept, and when the compound is used as an effective component to enter the human body, the activity of the ginkgolides K can be fully developed to achieve theaim of treating an illness.

Description

[0001] This application is a divisional application of CN200510094106.3, the application date of the original application is August 25, 2005, the application number is CN200510094106.3, and the name of the invention is: Ginkgolide K and its complex and its preparation method and application . technical field [0002] The invention relates to a ginkgolide substance and a compound thereof; in particular, a ginkgolide K and a compound thereof, and also relates to a preparation method and application of the ginkgolide K and the compound thereof. Background technique [0003] Ginkgolide is an effective substance extracted from Ginkgo biloba, a Chinese herbal medicine. The substance can be further subdivided into ginkgolide A, B, C, bilobalide, etc. The extraction method of ginkgolide has been detailed. For example, Li Xingang et al. introduced the laboratory extraction method of ginkgolide (see Li Xingang et al., Research on the laboratory extraction method of ginkgolide in Ginkg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/22C07C279/14C07C277/08C07C229/26C07C227/16C07C215/10C07C213/08A61K31/365A61P9/10A61P7/02A61P25/28A61P37/06A61P29/00A61P37/08A61P9/00
Inventor 肖伟戴翔翎凌娅李明慧丁岗章晨峰
Owner JIANGSU KANION PHARMA CO LTD
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