Cycloartenyl ferulate solid dispersion and preparation thereof

A technology of pineapplenyl ferulic acid ester and solid dispersion, which is applied in the field of medicine and can solve the problems of poor bioavailability and low solubility of cycloartenyl ferulic acid ester monomer
CN102058538BActive Publication Date: 2012-08-22BEIJING CENTURY BIOCOM PHARMA TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING CENTURY BIOCOM PHARMA TECH
Publication Date
2012-08-22

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Abstract

The invention discloses cycloartenyl ferulate solid dispersion, which comprises cycloartenyl ferulate and povidone serving as a carrier material. The invention further discloses a medicinal preparation and a preparation method of the solid dispersion. Experiments prove that the solid dispersion makes obvious technical progress in technical indexes such as dissolution rate, stability, water solubility, bioavailability and the like.
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Description

technical field

[0001] The invention discloses a solid dispersion of cycloartenol ferulate, which comprises cycloartenol ferulate and povidone as a carrier, and belongs to the field of medicine. Background technique

[0002] Oryzanol is a natural mixture composed of cycloartenol-based ferulic acid esters and sterol-based ferulic acid esters, and its appearance is white or light yellow crystalline powder. In rice bran oil oryzanol, the content of cycloartenol ferulate is about 70-80%. Long-term studies have found that oryzanol has a variety of pharmacological activities, including: lowering blood lipids, lowering cholesterol absorption, preventing lipid oxidation, and preventing cardiovascular diseases. In addition, recent studies have also found that oryzanol can alleviate various physical disorders and autonomic nervous disorders in women after menopause, and improve diencephalic dysfunction.

[0003] Oryzanol is easily soluble in organic solvents such as chloroform and a...

Claims

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