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Penicillins medicine capsule and preparation method of same

A penicillin and drug technology, applied in the field of medicine, can solve the problems of poor compliance, affecting the therapeutic effect of penicillin drugs, and large proportion of excipients.

Inactive Publication Date: 2016-08-10
HAINAN TANGCHENSHIKE BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, penicillin drug capsules are one of the commonly used drug dosage forms, but the capsules themselves have certain shortcomings, such as not being able to disintegrate rapidly when exposed to water, low dissolution rate and dissolution rate, poor absorption, and a large proportion of excipients. The elderly, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of penicillins

Method used

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  • Penicillins medicine capsule and preparation method of same
  • Penicillins medicine capsule and preparation method of same
  • Penicillins medicine capsule and preparation method of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation of capsule shell containing hydroxypropyl starch

[0035] prescription:

[0036] Raw materials

Dosage

Hydroxypropyl starch

80g

Carrageenan

7g

Chitosan

5g

Sodium Citrate

3.5g

Triethyl Citrate

2.7g

Propylene Glycol

2g

[0037] Preparation:

[0038] (1) Gelatinization: Put purified water into the gelatinization tank, heat it to 80-100℃, then add hydroxypropyl starch, keep stirring for 90-180min; then add the remaining ingredients, stir for 10-15min, add activated carbon and stir for decolorization 15min, filter to the incubator for temporary storage;

[0039] (2) The obtained glue solution is processed into a hydroxypropyl starch hollow capsule shell by a fully automatic hollow capsule manufacturing machine.

Embodiment 2a-2d

[0060] Examples 2a-2d Preparation of amoxicillin capsule contents (0.25g specification, 1000 capsules)

[0061] excipient

[0062] Preparation Process:

Embodiment 2a

[0064] 1. Mix amoxicillin and magnesium stearate evenly and set aside.

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PUM

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Abstract

The invention provides a penicillin medicine capsule, wherein a capsule shell containing hydroxypropyl starch can maintain the capsule to be stable and prevent the materials in the capsule shell from being wetted and penicillin from being degraded, thereby increasing in-vitro dissolubility and bioavailability of the capsule and further improving quality stability of the capsule.

Description

Technical field [0001] The invention relates to a penicillin capsule, specifically a capsule with a capsule shell containing hydroxypropyl starch, which belongs to the technical field of medicine. Background technique [0002] Capsules are widely used in the pharmaceutical industry. As one of the main ingredients, the capsule shell is a kind of shell that protects the medicine. It not only protects the medicine from being destroyed, but also reduces the irritation of the medicine to the respiratory tract and digestive organs. Therefore, a capsule preparation that is safe, effective, quality controllable and has good pharmacoeconomic value has good economic value and pharmaceutical value. [0003] Traditional gelatin capsules have many safety risks, because traditional gelatin capsules use animal protein colloidal gelatin prepared by hydrolysis of animal skin and bone as the capsule shell material. Due to limited sources, unscrupulous merchants use processed scraps of industrial le...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/43A61K31/431A61K47/36
CPCA61K9/4816A61K9/1617A61K9/1652A61K9/4858A61K9/4866A61K31/43A61K31/431
Inventor 朱正兵
Owner HAINAN TANGCHENSHIKE BIOLOGICAL TECH CO LTD
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