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Device and method for separating orange oil from honey pomelo essential oil by supercritical fluid chromatography

A supercritical chromatography and separation device technology, applied in the field of supercritical carbon dioxide chromatographic separation devices, can solve problems such as inability to extract high-purity orange olein, difficulty in recovery of orange olein, organic solvent residues, etc., and achieve no solvent residue and operation. Easy and efficient recycling

Active Publication Date: 2011-06-15
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is simple in process and takes a short time, but consumes a lot of solvent and it is difficult to recover orange olein
The above-mentioned traditional extraction and separation methods of orange olein are only suitable for the separation and analysis of a small amount of orange olein in the laboratory, and there are organic solvent residues in the orange olein product. At present, these methods cannot meet the requirements of extracting and separating a large amount of high-purity orange oil. prime requirements

Method used

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  • Device and method for separating orange oil from honey pomelo essential oil by supercritical fluid chromatography
  • Device and method for separating orange oil from honey pomelo essential oil by supercritical fluid chromatography
  • Device and method for separating orange oil from honey pomelo essential oil by supercritical fluid chromatography

Examples

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Effect test

Embodiment 1

[0035] Example 1: Pomelo essential oil, obtained by steam distillation from pomelo peel, wherein the anerene content is 0.785wt% (weight), provided by Fujian Guonong Agricultural Development Co., Ltd. Carbon dioxide, food grade, purity ≥ 99.5%, provided by Xiamen Linde Gas Co., Ltd. Operating conditions: pressure 10MPa, temperature 313K, carbon dioxide flow rate 5.0L / min. The recovery rate of the obtained anerene product was 88.2%, and the concentration was 37.8wt%.

Embodiment 2

[0036] Example 2: Pomelo essential oil, obtained by steam distillation from pomelo peel, wherein the anerene content is 0.785wt% (weight), provided by Fujian Guonong Agricultural Development Co., Ltd. Carbon dioxide, food grade, purity ≥ 99.5%, provided by Xiamen Linde Gas Co., Ltd. Operating conditions: pressure 20MPa, temperature 323K, carbon dioxide flow rate 9.5L / min. The recovery rate of the obtained anerene product was 92.5%, and the concentration was 64.6wt%.

Embodiment 3

[0037] Example 3: Pomelo essential oil, obtained by steam distillation from pomelo peel, wherein the anerene content is 0.785wt% (weight), provided by Fujian Guonong Agricultural Development Co., Ltd. Carbon dioxide, food grade, purity ≥ 99.5%, provided by Xiamen Linde Gas Co., Ltd. Operating conditions: pressure 30MPa, temperature 313K, carbon dioxide flow rate 9.8L / min. The recovery rate of the obtained anerene product was 96.7%, and the concentration was 78.4wt%.

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Abstract

The invention relates to a device and a method for separating orange oil from honey pomelo essential oil by supercritical fluid chromatography and relates to a supercritical fluid chromatographic separation technology. The device comprises a carbon dioxide storage tank, a filter, a low-temperature cooling liquid circulating pump, a carbon dioxide high-pressure pump, an essential oil storage tank, an essential oil metering pump, an essential oil batchmeter, an exhaust switching valve, a chromatographic column, an on-line high-pressure ultraviolet spectrophotometer, an on-line chromatographic detection work station, a pressure regulating valve, a collection switching valve, a flowmeter, two separation collectors, a constant-temperature heater, a constant-temperature cooler and a temperature controller. During separation, the essential oil metering pump is started and essential oil is pumped into the essential oil batchmeter by the essential oil metering pump; the low-temperature cooling liquid circulating pump and the carbon dioxide high-pressure pump are started and carbon dioxide enters the essential oil batchmeter, so that fluid in the essential oil batchmeter enters the chromatographic column; the flow quantity of the carbon dioxide flowing out of the separation collector is metered by the flowmeter; each fraction product is recovered at the bottom of the separation collector; and the concentration and the recovery rate of the orange oil fraction product can be obtained through calculation.

Description

technical field [0001] The invention relates to a supercritical chromatographic separation technology, in particular to a supercritical carbon dioxide chromatographic separation device and method for the anticancer component anerene in honey pomelo essential oil. Background technique [0002] Orange olein is an important natural anti-cancer active substance, its structural formula is: [0003] [0004] It can inhibit or prevent the occurrence and development of various cancer tumors such as skin, oral cavity, esophagus, intestine, lung, liver, etc. Several clinical research papers published by Tanaka.T and Hirose.Y in international authoritative journals such as Cancer Research, Carcinogenesis, Oncology, and Clinical Cancer Research have confirmed that orange olein has a good inhibitory effect on the above-mentioned cancer tumors. Heterene widely exists in the peel and pulp of citrus fruits, Ogawa.K et al. (1.K.Ogawa, A.Kawasaki, T.Yoshida, H.Nesumi, M.Nakano, Y.Ikoma, M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/16B01D15/40
CPCY02P20/54
Inventor 王宏涛赵凯歌李军苏玉忠
Owner XIAMEN UNIV
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