Application of blood plasma miR-208a in early marker for diagnosis of acute myocardial infarction

A technology of mir-208a, acute myocardial infarction, applied in the field of medical molecular biology
CN102134585AInactive Publication Date: 2011-07-27SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2011-07-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses the new purpose of blood plasma miR-208a in an early marker for the diagnosis of acute myocardial infarction. The miRNA only has 18 to 25 nucleotide, and a mature body of the miRNA stably exists in cytoplasm, therefore, after the occurrence of the acute myocardial infarction, the miRNA is released into circulating blood earlier than structural protein substances (such as troponin), the raise of level can be detected at the early stage of myocardial infarction, and the blood plasma miR-208a can be used as the early marker for the diagnosis of acute myocardial infarction. With regard to the diagnoses to patients at the early stage of myocardial infarction (within three hours of stethalgia), good specific markers are currently unavailable, therefore, the blood plasma miR-208a has broad market prospect in finding out the marker applicable to the early diagnosis of acute myocardial infarction.
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Description

【Technical Field】

[0001] The present invention relates to the technical field of medical molecular biology, and more specifically, to the new use of plasma miR-208a as an early marker for the diagnosis of acute myocardial infarction. 【Background technique】

[0002] MicroRNA (miRNA) is a type of endogenous non-coding small RNAs with only 18-25 nucleotides, which are widely present in various organisms. miRNA binds to the 3'untranslated region (3'-UTR) of target gene mRNA, degrades or inhibits mRNA translation, regulates the expression of target genes, and participates in regulating various biological functions. In 1993, Ambros first discovered a non-coding single-stranded small molecule RNA-lin4 in C. elegans, which has the function of regulating the developmental phase of C. elegans. After nearly 20 years of scientific research, 721 miRNAs (Sanger miRbase 14.0) have been discovered in the human body. These miRNAs play an important regulatory role in many life activities of the h...

Claims

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