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Chinese medicinal composition for promoting nerve regeneration and preparation method and use thereof

A technology for nerve regeneration and composition, applied in the directions of drug combination, application, food preparation, etc., can solve the problems of limitation of wide application, expensive manufacturing cost, etc., and achieve the effect of wide application value, low dosage, and excellent effect of promoting nerve regeneration.

Active Publication Date: 2013-04-24
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although the formula has a good effect of resisting cerebral ischemic injury and improving learning and memory, because the formula is a pure chemical composition formula, the source of raw materials of each component is subject to certain restrictions, the manufacturing cost is relatively expensive, and its wide application is limited.
[0009] Promoting nerve regeneration is a new treatment trend and future development direction for the treatment of cerebral ischemic diseases, but there are few reports on traditional Chinese medicine in this regard

Method used

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  • Chinese medicinal composition for promoting nerve regeneration and preparation method and use thereof
  • Chinese medicinal composition for promoting nerve regeneration and preparation method and use thereof
  • Chinese medicinal composition for promoting nerve regeneration and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of total extract of traditional Chinese medicine compound (WSXN1)

[0048] Shouwu 100 kg, ginseng 90 kg, ginkgo leaves 60 kg.

[0049] Take the prescribed amount of ginseng, crush it into a coarse powder, and extract 10 times, 8 times and 6 times the amount of medicinal materials by refluxing 60% ethanol for 3 times, each time for 2 hours, combine the extracts, recover the ethanol under vacuum and decompression, and make it The concentration of alcohol extraction part is 1 ml is equivalent to 1 g crude drug.

[0050] The treatment method of Ginkgo biloba is the same as that of ginseng, and the concentration of the final alcohol extraction part is 1 ml, which is equivalent to 1 g of crude drug.

[0051] Shouwu was decocted and extracted 3 times with 10 times, 8 times and 6 times of the amount of medicinal materials, each time for 2 hours, combined 3 times of water extracts, and concentrated under vacuum to 1ml of the extract, which is equivalent ...

Embodiment 2

[0056] Example 2 Preparation of total extract of traditional Chinese medicine compound (WSXN1-2)

[0057] Shouwu 100 kg, ginseng 90 kg, ginkgo leaves 60 kg.

[0058] The above medicinal materials are crushed into coarse powder, boiled with 12 times, 10 times and 6 times the amount of medicinal materials in water for 2 h, 1.5 h and 1 h respectively, filtered, and the combined filtrates are concentrated to 1 ml under reduced pressure at 80 °C Equivalent to containing 1g crude drug, add 95% ethanol to make the alcohol content reach 70%, let it stand overnight, filter the ethanol solution to recover ethanol under vacuum and reduce pressure, concentrate to obtain 1g medicinal material / ml concentrated alcohol extract, and divide the total alcohol extract The concentrated solution is added to the treated macroporous adsorption resin (PD100 polystyrene weakly basic anion exchange resin), and the dosage ratio of the macroporous resin to the concentrated solution is 1kg of macroporous...

Embodiment 3

[0062] Example 3 Preparation of Shouwu, Ginseng, and Ginkgo Leaf Extracts

[0063] 1 Preparation of Shouwu Extract 1

[0064] Take 500 kg of Polygonum multiflorum and crush it into a coarse powder, and extract 3 times with 70% ethanol with 10 times, 8 times and 6 times the weight of the medicinal material under reflux, each time for 2 hours, combine the extracts, recover ethanol under vacuum and decompression and make the alcohol The concentration of the extracted part is 1 ml of total alcohol extract equivalent to 1 g of crude drug; the total alcohol extract is added to the treated macroporous adsorption resin (PD100 polystyrene weakly basic anion exchange resin), and the The dosage ratio of the alcohol extract is 1kg macroporous resin plus 2L of the total alcohol extract. Use 50%, 70%, 80% and 95% ethanol to elute sequentially, the dosage is 4 L, elute at a flow rate of 10 ml / min, collect the corresponding eluent, recover ethanol, dry; plaster, vacuum-dried, and pulveriz...

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Abstract

The invention discloses a traditional Chinese medicine composition for promoting nerve regeneration, a preparation method and application thereof. The traditional Chinese medicine composition for promoting nerve regeneration of the present invention is composed of 2 to 10 parts of Shouwu, 1 to 10 parts of ginseng and 1 to 10 parts of ginkgo leaves; commercially available Shouwu extracts, ginseng extracts and ginkgo leaves can also be used to extract Composition according to proportion. In addition to the preparation by the conventional method, the present invention also provides a preparation method of the traditional Chinese medicine composition, which is to obtain the C1-3 alcohol extract after the raw drug is subjected to C1-3 alcohol extraction, and pass through the macroporous adsorption resin column after concentration ethanol elution, collecting eluate, recovering ethanol, and drying; or recovering ethanol, concentrating into a thick plaster, drying and pulverizing to obtain the final extract, and mixing to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition of the present invention has obvious effect of promoting nerve regeneration, and has anti-cerebral ischemic injury, neuroprotection, improvement of learning and memory, and anti-senile dementia effects, and has clear main active ingredients, stable quality, and low dosage, and is an excellent natural medicine or health food.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for promoting nerve regeneration and its preparation method and application. Background technique [0002] Diseases related to cerebral ischemic injury include stroke, sequelae of stroke, and vascular dementia. Ischemic stroke is an important killer that threatens human health, and its incidence is very high in middle-aged and elderly people. It is estimated that there are nearly 5 million ischemic stroke patients in the country, and more than 20 million people worldwide, and the age of onset is getting younger and younger. Many ischemic stroke patients lose their ability to work, which seriously damages the social labor force and creativity. [0003] Alzheimer's disease is a common disease in the elderly, and there are different types such as vascular dementia (Vascular Dementia, VD) and senile dementia (Alzheime...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A23L1/29A61P9/10A61P25/28A23L33/00
CPCA61K36/16A61K36/258A61K36/70A61P9/10A61P25/28A61K2300/00
Inventor 贝伟剑郭姣
Owner GUANGDONG PHARMA UNIV
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