Methods and compositions for diagnosis and prognosis of renal injury and renal failure

A technology of kidney function and kidney status, which is applied in disease diagnosis, biological testing, biomaterial analysis, etc., and can solve problems such as inability to distinguish types or locations

Inactive Publication Date: 2011-11-16
ASTUTE MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because serum creatinine is a marker of filtration rate, it is not possible to differentiate the etiology of AKI (prorenal, intrarenal, metanephric obstruction, atherosclerotic embolism, etc.) or the type or location of intrarenal disease (eg, tubular, renal glomerulus or renal space)

Method used

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  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Examples

Experimental program
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preparation example Construction

[0195] Preparation of solid phase and detectably labeled conjugates typically involves the use of chemical crosslinkers. Crosslinkers include at least two reactive groups, and can be classified into homofunctional crosslinkers (comprising the same reactive groups) and heterofunctional crosslinkers (comprising non-identical reactive groups). Biologically functional cross-linkers that conjugate non-specifically via amines, thiols, or reactions are available from a number of commercial sources. Maleimides, alkyl and aryl halides, and α-haloacyls react with thiols to form thioether linkages, while pyridyl disulfides react with sulfhydryls to form mixed disulfides. The pyridyl disulfide product is cleavable. Imidates are also very useful for protein-protein crosslinks. A variety of xenobiofunctional crosslinkers, each incorporating different features for successful conjugation, are commercially available.

[0196] In some aspects, the invention provides kits for analyzing said k...

Embodiment 1

[0234] Example 1: Sample collection of contrast agent-induced nephropathy

[0235] The purpose of this sample collection study was to collect plasma and urine samples as well as clinical data from patients before and after receiving intravascular contrast media. Approximately 250 adults underwent a radioimaging / angiography procedure involving intravascular administration of iodinated contrast medium. In order to participate in this study, each patient must meet the following selection criteria and not meet the following exclusion criteria:

[0236] selection criteria

[0237] Men and women 18 years of age or older;

[0238] Have undergone a radiographic / angiographic procedure (e.g., CT scan or coronary intervention), including intravascular administration of contrast media;

[0239] Admission to the hospital is expected to be at least 48 hours after contrast administration.

[0240] Can and will provide written informed consent for study participation and adherence to all ...

Embodiment 2

[0251] Embodiment 2: cardiac surgery sample collection

[0252] The purpose of this sample collection study was to collect plasma and urine samples as well as clinical data from patients before and after undergoing cardiovascular surgery, a procedure known to be potentially damaging to renal function. About 900 adults who underwent the procedure participated. In order to participate in the study, each patient must meet all of the following selection criteria and none of the exclusion criteria:

[0253] selection criteria

[0254] Men and women 18 years of age or older;

[0255] have undergone cardiovascular surgery;

[0256] A kidney replacement risk score of at least 2 on the Toronto / Ottawa Predictive Risk Index (Wijeysundera et al., JAMA 297:1801-9, 2007); and

[0257] Can and will provide written informed consent for study participation and adherence to all study steps.

[0258] exclusion criteria

[0259] pregnant;

[0260] previous kidney transplant;

[0261] Acut...

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Abstract

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble CD44 antigen, Angiopoietin-1, soluble Angiopoietin-1 receptor, C-X-C chemokine motif 5, soluble Endoglin, soluble Tumor-associated calcium signal transducer 1, Erythropoietin, soluble Fractalkine, Heme oxygenase 1, soluble Interleukin-1 receptor type II, soluble Interleukin-6 receptor subunit-alpha, Lymphotactin, Lymphotoxin-alpha, Stromelysin-1, C-C motif chemokine 22, C-C motif chemokine 5, and Thrombospondin-1 as diagnostic and prognostic biomarkers in renal injuries.

Description

[0001] This invention claims U.S. Provisional Patent Application 61 / 107,287, filed October 21, 2008, U.S. Provisional Patent Application 61 / 117,138, filed November 22, 2008, U.S. Provisional Patent Application 61 / 113,034, filed November 10, 2008 , U.S. Provisional Patent Application 61 / 115,050, filed November 15, 2008, U.S. Provisional Patent Application 61 / 113,078, filed November 10, 2008, U.S. Provisional Patent Application 61 / 113,039, filed November 10, 2008, 2008 U.S. Provisional Patent Application 61 / 117,143 filed November 22, 2008, U.S. Provisional Patent Application 61 / 107,307, filed October 21, 2008, U.S. Provisional Patent Application 61 / 113,069, filed November 10, 2008, October 2008 U.S. Provisional Patent Application 61 / 107,293 filed November 21, U.S. Provisional Patent Application 61 / 113,059 filed November 10, 2008, U.S. Provisional Patent Application 61 / 115,028 filed November 14, 2008, November 14, 2008 U.S. Provisional Patent Application 61 / 115,026 filed on Novembe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53G01N33/543G01N33/48
CPCG01N33/6893G01N2800/347G01N2800/60
Inventor J·安德贝里J·格雷P·麦克弗森K·中村
Owner ASTUTE MEDICAL
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