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Method for rapidly detecting lincomycin antibiotics in cosmetics

A technology of lincomycin and detection method, which is applied in the direction of material analysis by observing the influence on chemical indicators, and analysis by chemical reaction of the material, etc., can solve the problems of unsuitable rapid detection and long detection time, etc. Achieve intuitive and reliable inspection results, fast detection speed, and easy identification.

Inactive Publication Date: 2012-06-20
惠州市食品药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above method needs to use a variety of analysis and testing equipment, such as expensive high-performance liquid chromatography, and uses a variety of chemical reagents. The testing personnel need to have a strong level of detection equipment operation, and the detection time is too long, so this method is not suitable for simple Rapid detection under conditions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 A certain brand of acne-clearing-acne-clearing-removing facial cleanser

[0038] The acne-liquid-clearing-acne-de-printing cleansing milk of this example is a lotion cosmetics. First, prepare the experimental equipment:

[0039] Colorimetric tube with plug (25ml) and graduated tube.

[0040] Take about 1g of Acne Liqing Clear Acne De-printing Cleanser, place it in a colorimetric tube, add 10ml of water, shake several times to make the sample evenly dispersed, add 3ml of 1% sodium periodate solution and 2ml of 30% sulfuric acid solution, then add 10ml of cyclohexane, tightly stuffed, shake, and stand still, and gently shake up and down several times during the standing process. Observe the color change of the upper cyclohexane layer. The cyclohexane layer does not appear pink to purple, and it is judged as negative, which means that lincomycin antibiotics are not added to the test sample.

[0041] The sample was verified and confirmed by high performance liquid chro...

Embodiment 2

[0042] Example 2 A certain brand of acne spot cleansing white acne cream

[0043] The acne spot cleansing white acne cream in this embodiment is a cream type cosmetics. First, prepare the experimental equipment:

[0044] Colorimetric tube with plug (25ml) and graduated tube.

[0045] Take about 1g of acne spot clear white acne cream, put it in a colorimetric tube, add 10ml of water, shake several times to make the sample evenly dispersed, add 3ml of 1% sodium periodate solution and 2ml of 30% sulfuric acid solution, then add cyclohexane 10ml of alkane, densely plugged, shake, and stand still, gently shake up and down several times during the standing process. Observe the color change of the upper cyclohexane layer. The cyclohexane layer is pink, and it is judged to be positive, indicating that lincomycin antibiotics have been added to the sample to be tested.

[0046] The sample was verified and confirmed by high performance liquid chromatography (diode array detector) and liquid-m...

Embodiment 3

[0047] Example 3 A certain brand of high-efficiency anti-acne fairy water

[0048] The high-efficiency acne-removing fairy water in this embodiment is a solution cosmetic. First, prepare the experimental equipment:

[0049] Colorimetric tube with plug (25ml) and graduated tube.

[0050] Take about 2ml of high-efficiency acne-removing fairy water, put it in a colorimetric tube, add 3ml of 1% sodium periodate solution and 2ml of 30% sulfuric acid solution, then add 10ml of cyclohexane, tightly plug, shake, stand, and stand still. From time to time, gently shake up and down several times. Observe the color change of the upper cyclohexane layer. The cyclohexane layer is purple-red, and it is judged to be positive, indicating that lincomycin antibiotics have been added to the sample to be tested.

[0051] The sample was verified and confirmed by high performance liquid chromatography (diode array detector) and liquid-mass spectrometry technology, and the test results were consistent wit...

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Abstract

The invention relates to a method for detecting lincomycin antibiotics, in particular to a method for rapidly detecting the lincomycin antibiotics, and more particular to a method for rapidly detecting illegally-added lincomycin antibiotics in anti-acne cosmetics. The method for detecting the lincomycin antibiotics in cosmetics comprises the following steps of: adding a periodate solution, an acidic modifier and cyclohexane to a sample to be detected or sample solution to be detected; observing the color of an upper-layer solvent after 3-30 min; if the color is between pink and amaranthine, indicating that the sample to be detected contains the lincomycin antibiotics; and if a cyclohexane layer is not between pink and amaranthine, indicating that the sample to be detected contains no lincomycin antibiotics. The method provided by the invention can be used for achieving the purposes of targeted sampling and target testing and has the characteristics of simpleness, easiness for operation, rapidness in detection, accurate result, extremely low test cost and capability of rapidly screening a large number of samples.

Description

technical field [0001] The invention relates to a detection method for lincomycin antibiotics, in particular to a rapid detection method for lincomycin antibiotics, in particular to a rapid detection method for illegally added lincomycin antibiotics in cosmetics. Background technique [0002] In recent years, in order to make huge profits, some unscrupulous businesses have added antibiotics and other drugs to acne-removing cosmetics without authorization, so as to achieve the purpose of rapid effect, and lied about "natural Chinese herbal medicine extraction", bragging and exaggerating the curative effect. If consumers use it for a long time without knowing it, it will cause serious harm to their health. The inventor found through investigation and experiments that the phenomenon of illegally adding lincomycin antibiotics in acne-removing cosmetics on the market is more serious. [0003] Lincomycin antibiotics (Lincosamides) are antibiotics with activity against Gram-positi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78
Inventor 简淑娟林暖丹翁雪萍
Owner 惠州市食品药品检验所
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