Biological tissue moisture measurement device and method based on terahertz wave attenuated total reflectance (ATR)

Abstract

The invention relates to non-linear optical frequency conversion and the application of the non-linear optical frequency conversion and provides a method and a device which can widen the preparation requirements for a biological sample, do not need preparation of the sample, are high in measurement sensitivity, and can achieve high resolution, fast and real-time biological sample moisture content and distribution imaging measurement. The technical scheme is that the biological tissue moisture measurement device based on terahertz wave attenuated total reflectance (ATR) is composed of a tunable terahertz (THz) radiation source, a non-spherical face lens assembly, a total reflection prism, a two-dimensional mobile scanning platform, a terahertz wave detector and a computer. The total reflection prism is placed in the middle of the non-spherical face lens assembly, the face to be tested of a biological sample to be tested clings to the top face of the total reflection prism fixed on the two-dimensional mobile scanning platform, terahertz (THz) waves are projected to the terahertz detector through the non-spherical face lens assembly, and a detection result of the terahertz detector is output to the computer. The biological tissue moisture measurement device and the method based on the terahertz wave attenuated total reflectance (ATR) are mainly used for biological sample moisture content and distribution imaging measurement.

Description

technical field [0001] The present invention relates to nonlinear optical frequency conversion and its application, and in particular to the measurement of moisture content and distribution of biological tissue by using the principle of terahertz wave ATR imaging, that is, a device and method for measuring moisture content of biological tissue based on terahertz wave ATR imaging. Background technique [0002] Terahertz (Terahertz, referred to as THz, 1THz = 10 12 Hz) band refers to the frequency range from 100 GHz to 10 THz, the corresponding wavelength is from 3 mm to 30 microns, and the electromagnetic spectrum range is quite wide between millimeter wave and infrared light. Because this frequency band is the transition frequency band from macroelectronics to microphotonics, it has many unique properties, especially since the vibration and rotation frequencies of many biological macromolecules fall in the THz band, the emission, reflection and transmission of substances in ...

AI Technical Summary

Problems solved by technology

However, due to the serious absorption of THz waves by water, transmission measurement has very strict requirements on the thickness of the sample, which is only tens of microns, which requires special sample preparation and water retention methods, which increases the production cost and time cost of the sample.

And the thickness is close to the THz wave measurement wavelength, which is easy to produce interference fringes

In addition, the THz light source uses a silicon prism to couple and output an optical parametric oscillation radiation source, and the quality of the THz wave spot is poor, which directly affects the quality and resolution of the imaging, and restricts its practical application in the fields of scientific research, medical diagnosis, etc.

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