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Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing

A technology of bovine vine and health products, applied in the direction of medical preparations containing active ingredients, drug combinations, medical formulas, etc., to achieve the effects of promoting lead discharge, improving symptoms, and having no toxic and side effects

Active Publication Date: 2012-10-17
LIAONING UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Bovine vine is the stem and leaf of the Rubiaceae plant, which is sweet, light, cool in nature, and has the effect of clearing away heat and dampness; it is mainly used clinically in clearing away heat, relieving heat and eliminating dampness, but whether it has the effect of promoting lead excretion in the human body remains to be seen. No literature report

Method used

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  • Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 60 healthy Kunming mice, clean grade, half male and half female, weighing 20±2g, were divided into 5 groups, namely blank control group, lead-exposed model group, and 3 dosage groups of high, medium and low Caulis alba decoction , 12 mice in each group; lead acetate was dissolved in distilled water and injected intraperitoneally at 40 mg / kg to establish a lead-exposed mouse model.

[0015] The decoction of Niubai Teng was prepared by conventional decoction method. Different dosage groups of the decoction included high-dose group (10g / kg), middle-dose group (5g / kg), low-dose group (2.5g / kg). Oral administration, the other groups were given the same amount of normal saline, and the experiment continued for 6 weeks. After the administration, take 40ul of blood from the right femoral vein of the mouse, put it into a covered plastic centrifuge tube filled with 0.36ml of 1% nitric acid, and shake well; take 50% of the femur on one side, weigh it and digest it, add dilute nitr...

Embodiment 2

[0021] Preparation of the test substance: Weigh the same amount of Caulis chinensis, chrysanthemum and Haijinsha, and prepare it by conventional water decoction. The different dosage groups of the prepared test substance include the high-dose group (20g / kg), the middle-dose group (10g / kg) , low-dose group (5g / kg), each group was given intragastric administration, and the other groups were given the same amount of normal saline, and the experiment continued for 6 weeks. After the administration, take 40ul of blood from the right femoral vein of the mouse, put it into a covered plastic centrifuge tube filled with 0.36ml of 1% nitric acid, and shake well; take 50% of the femur on one side, weigh it and digest it, add dilute nitric acid to make it to 5ml , and the liver and brain tissue were taken, and the blood, bone, liver, and brain lead content were measured with an atomic spectrophotometer. Data statistics use T test. The results are shown in Table 2 below.

[0022]

[0...

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Abstract

The invention relates to application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing. An adoptive technical scheme is as follows: the lead-removing drug or health product is prepared from Caulis et Folium Hedyotis Hedyotideae or decoction thereof individually or in combination with other lead-removing drugs (one or combination of Fructus Lycii, Flos Chrysanthemi, Spora Lygodii, Herba Plantaginis, and Semen Cassiae). According to the invention, Caulis et Folium Hedyotis Hedyotideae with lead removal promoting effect is selected, thereby achieving the aim of relieving or preventing lead damage to human body, and improving symptoms; Caulis et Folium Hedyotis Hedyotideae has no toxic and side effects; and is suitable for long-term administration by population with high blood lead, and is also suitable for children with high blood lead.

Description

technical field [0001] The invention relates to the field of application of the traditional Chinese medicine Caulis chinensis, specifically its use in the preparation of health care products or medicines that promote the role of lead excretion in the body. Background technique [0002] Lead is a heavy metal element, which is a non-essential element for the human body. It has a strong affinity for body tissues, interferes with the essential elements of the human body, disturbs the physiological combination and ratio relationship balance of the essential elements in the human body, and thus disturbs the enzyme system in the body. And the physiological activity of biological macromolecules, so that the enzyme system in the body loses its normal physiological activity and other regulation functions that regulate the balance of body functions become disordered, which in turn affects the functions of multiple physiological systems of the human body. [0003] Theoretically, the lea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P39/02
Inventor 蔡天革唐凤德
Owner LIAONING UNIVERSITY
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