Method for evaluating cigarette harm degree by using primate animal models

An animal model and primate technology, which is applied in the field of evaluation of the harm reduction effect of cigarettes constructed by primates, can solve problems such as the inappropriateness of tobacco animal testing, and achieve the effects of low evaluation cost, perfect evaluation system and convenient operation.

Inactive Publication Date: 2012-11-21
HUBEI CHINA TOBACCO IND +1
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Problems solved by technology

The cigarette industry also needs to conduct animal tests on the toxicity of tobacco, but the dynamic inhalation system of the prior art is not suitable for animal tests on tobacco

Method used

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  • Method for evaluating cigarette harm degree by using primate animal models
  • Method for evaluating cigarette harm degree by using primate animal models
  • Method for evaluating cigarette harm degree by using primate animal models

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Embodiment 1

[0029]The present embodiment is for Chinese tree shrews exposed to tobacco. Taking Chinese tree shrews that have not been exposed to tobacco as a control group, each test in the method of the present invention is carried out. The results are as follows: Compared with Chinese tree shrews that have not been exposed, tobacco exposed The respiratory frequency of the Chinese tree shrews after exposure was significantly lower than that of the control group, and the number of coughs per minute was between 41 and 69 times, and the feed utilization rate showed a transient decrease; when the smoke was exposed, the Chinese tree shrews in the exposure group showed inhibition The obvious reaction of excitement, a certain degree of addiction to smoke appeared after 8W; at the same time, it was found that after 12W exposure, one case of Chinese tree shrews in the exposure group had obvious neurological symptoms, and its movement posture changed significantly; The content of SOD was significan...

Embodiment 2

[0034] The research date of this embodiment is from February 2010 to August 2010. This embodiment takes the primate experimental animal Chinese tree shrew as the research object, and comparatively analyzes that the Chinese tree shrew is placed in the poisoning box of the active smoking device of the animal experiment, and after the smoke exposure is carried out with cigarette samples No. 10 and No. 11 respectively, the experimental animals Harm reduction and its mechanism of Chinese tree shrews. [Test method] In this study, an animal active smoking device consisting of a SHZ-D(III) circulating water multi-purpose vacuum pump (produced by Yuhua Instrument Co., Ltd., Gongyi, China), an electromagnetic flowmeter, and an automatic closing device was used. 1. According to the smoke volume of burning 5 sample cigarettes / piece / day as the exposure dose, put Chinese tree shrews in the airtight active smoking device, and the net smoke inhalation time is 15mins / d / piece. The exposure per...

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Abstract

The present invention discloses a method for evaluating a cigarette harm degree by using primate animal models, and belongs to the field of cigarette toxicology evaluation and related technology detection. According to the method, Chinese tree shrews are adopted as test animals, an active smoking device with a special design is adopted to enable tested animals to be at a smoking stimulating state so as to observe conditions of the animals at the state, determine real test data, and reasonably evaluate a cigarette harm degree. The method of the present invention has the following advantages that: the specific Chinese tree shrews with high biological classification are adopted to carry out evaluation researches of tobacco toxicology and attenuated mechanisms, wherein the method has characteristics of sensitive response on toxicological effects produced by cigarette smoke gas, convenient operation and economic breeding, the evaluation system used in the method is perfect, the evaluation cost is relatively low, the evaluation result obtained by using the primate animal models provides comparative medicine values compared with the evaluation result obtained by using other experimental animals, and the method is applicable for evaluation of cigarette harm reduction efficacy.

Description

technical field [0001] The invention belongs to the field of cigarette toxicological evaluation and related technical detection, and in particular relates to an evaluation method for constructing cigarette harm-reducing efficacy with primates. Background technique [0002] In the prior art, in order to reduce the harm that smoking brings to mankind, the World Health Organization (WHO) has listed "anti-smoking" as the three major action goals in the health field in the 21st century (anti-malarial, anti-smoking and helping the poor). )one. When evaluating the damage of smoking to the body, it is necessary to establish a suitable smoking animal model to study the damage mechanism of the toxicants contained in the smoke. [0003] At present, the animals used in smoking exposure experiments mainly include rodents (such as mice, rats, guinea pigs, hamsters, etc.) and primates such as monkeys. Animal models of lung cancer also mostly choose animals such as mice, rats, hamsters, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48A61K49/00
Inventor 宋旭艳周顺长魏敏吴健鸿曾繁典
Owner HUBEI CHINA TOBACCO IND
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