Sargassum polysaccharide and application of Sargassum polysaccharide in medicine preparation used for treating kidney injury

A technology for sargassum polysaccharides and kidney damage, which is applied in the field of sargassum polysaccharides and its application in the preparation of drugs for kidney damage, and can solve the problem of less drugs

Inactive Publication Date: 2012-11-28
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many scholars are committed to reducing the nephrotoxicity induced by gentamicin, cisplatin and ethylene glycol, but there are few drugs that can be applied clinically.

Method used

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  • Sargassum polysaccharide and application of Sargassum polysaccharide in medicine preparation used for treating kidney injury
  • Sargassum polysaccharide and application of Sargassum polysaccharide in medicine preparation used for treating kidney injury
  • Sargassum polysaccharide and application of Sargassum polysaccharide in medicine preparation used for treating kidney injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The application of a sargassum polysaccharide in the preparation of medicine for kidney damage.

[0021] The medicine is composed of sargassum polysaccharide and a pharmaceutically acceptable carrier.

[0022] The kidney protection drug is tablet or oral liquid, injection or powder injection.

[0023] Application of a sargassum polysaccharide in the preparation of kidney damage health products.

[0024] The health care product is composed of sargassum sargassum polysaccharide and an acceptable carrier in the field of health care products.

[0025] The kidney protection health product is tablet or oral liquid or capsule preparation.

[0026] Sargassum polysaccharides fight against kidney damage caused by drugs and chemicals such as gentamicin, cisplatin, and high oxalic acid.

[0027] The sargassum polysaccharide is an active extract from sargassum sargassum.

[0028] Animal grouping and dosage

[0029] 36 healthy SD males (180-220g) were randomly divided into contr...

Embodiment 2

[0056] Renal protection drugs and health care products made from Sargassum sargassum polysaccharides

[0057] 1. Tablet

[0058] (1) The preparation prescription is as follows:

[0059]

[0060] (2) The preparation process is:

[0061] ① Extraction and separation: according to the aforementioned extraction method from 草叶马尾藻 extract and separate polysaccharides from the

[0062] ② Refining: the above-mentioned Sargassum sargassum polysaccharide is concentrated to a thick paste of a certain concentration

[0063] ③Granulation: Take 10g of the above-mentioned thick paste-like Sargassum polysaccharide, add an appropriate amount of ethanol, starch and dextrin soft material, pass through a No. 1 sieve (12-14 mesh) to make granules;

[0064] ④ Drying: put the wet granules prepared above in a drying oven to dry quickly, and dry at 60°C for 24 hours;

[0065] ⑤ Tablet compression: add talcum powder and magnesium stearate, mix well, press into 1000 tablets, coat with sucrose sug...

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Abstract

The invention relates to an application of Sargassum polysaccharide in medicine preparation used for treating kidney injury, the Sargassum polysaccharide is an active extract total polysaccharide in Sargassum graminifolium, the invention specifically relates to an application of Sargassum polysaccharide in kidney protection, and an application of Sargassum polysaccharide which can be mixed or individually used as antidotes in the pharmacy fields. The results show that the Sargassum graminifolium polysaccharide has certain protection effect on rat kidney, and can resist the kidney injury caused by medicines and chemicals such as gentamycin, cisplatin and high oxalic acid and the like.

Description

【Technical field】 [0001] The invention relates to the technical field of medicines for kidney damage, in particular to a sargassum polysaccharide and its application in the preparation of medicines for kidney damage. 【Background technique】 [0002] In recent years, with the wide application of various chemical substances and drugs, it has also brought negative effects, affecting the health of the people. For example, the use of milk powder containing melamine induces kidney stones, causing kidney damage, leading to kidney inflammation and Pathological changes such as fibrous tissue hyperplasia further cause renal metabolic dysfunction, increase the content of blood urea nitrogen and creatinine, and eventually renal failure will occur. The drugs gentamicin and cisplatin can both cause acute kidney injury, which is characterized by a rapid increase in blood creatinine (SCr) and blood urea nitrogen (BUN). Many studies have shown that cisplatin-induced nephrotoxicity is a compl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P13/12A23L1/29C08B37/00A23L33/00
Inventor 蓝闽波张朝燕袁慧慧赵红莉王呈仲刘进进
Owner EAST CHINA UNIV OF SCI & TECH
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