Medicinal composition containing zafirlukast and statins

A technology of composition and medicine, which is applied in the field of medicine, can solve problems that have not been reported, and achieve good therapeutic effects, lower incidence rates, and increased treatment compliance

Inactive Publication Date: 2012-12-19
HAIMEN THE YELLOW SEA ENTREPRENEURSHIP PARK SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, zafirlukast and statins are used as a compound to treat respiratory diseases, which has not been reported in the prior art

Method used

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  • Medicinal composition containing zafirlukast and statins
  • Medicinal composition containing zafirlukast and statins
  • Medicinal composition containing zafirlukast and statins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 tablet

[0032]

[0033] Preparation process: Mix pravastatin, zafirlukast and auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make a soft material, and pass through a 16-mesh sieve to granulate. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0034] The preparation of embodiment 2 tablet

[0035]

[0036] Preparation process: Mix rosuvastatin, zafirlukast and auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make a soft material, and pass through a 16-mesh sieve to granulate. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 3

[0037] The preparation of embodiment 3 tablet

[0038]

[0039] Preparation process: Mix rosuvastatin, zafirlukast and auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make a soft material, and pass through a 16-mesh sieve to granulate. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

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PUM

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Abstract

The invention belongs to the field of medicine technology, provides a medicinal composition containing zafirlukast and statins, and also provides application of the medicinal composition in preparation of medicines for treating asthma disease. The medicinal composition provided by the invention specially contains two medicinal active components of zafirlukast and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor, wherein the mass ratio of zafirlukast to the 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor is 1 to (0.01-10). In addition, a compound preparation provided by the invention can be prepared into an orally administered preparation or a parentarally administered preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition of zafirlukast and statins. Background technique [0002] Bronchial asthma (asthma for short) is a kind of chronic airway inflammation, which is a chronic inflammation of the airway in which a variety of inflammatory cells participate. It is characterized by reversible airway obstruction and increased airway reactivity. Airway obstruction is caused by increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; and increased airway reactivity is also due to airway inflammation. result of damage to the bronchial epithelium. It has been recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and relieving asthma symptoms be achieved. Most of the current research focuses on the airway, and it is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/404A61K31/505A61P11/06
Inventor 刘树芹
Owner HAIMEN THE YELLOW SEA ENTREPRENEURSHIP PARK SERVICE CO LTD
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