Preparation method of hydroxyapatite nanoneedles and prepared nanoneedles

A technology of hydroxyapatite and nanoneedles, applied in the field of biomedical materials, can solve the problems of sodium fluoride toxicity and environmental hazards

Inactive Publication Date: 2012-12-26
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, sodium fluoride is often added to toothpaste to prevent caries, but sodium fluoride is toxic and harmful to the environment, while nano-hydroxyapatite has a certain adsorption effect, and nano-hydroxyapatite has no toxic side effects , no pollution to the environment, so the use of nano-hydroxyapatite particles to adsorb and remove these substances related to plaque formation is of great significance to oral health care

Method used

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  • Preparation method of hydroxyapatite nanoneedles and prepared nanoneedles
  • Preparation method of hydroxyapatite nanoneedles and prepared nanoneedles
  • Preparation method of hydroxyapatite nanoneedles and prepared nanoneedles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A method for preparing hydroxyapatite nanoneedles, comprising the following steps:

[0034] (1) Take 700mL of deionized water and add it to a 1000mL plastic beaker, put it in a collector type magnetic stirrer, oil bath, magnetic stirring, set the temperature at 37°C. 8.035g NaCl, 0.355g NaHCO 3 , 0.225g KCl, 0.231g K 2 HPO 4 ·3H 2 O, 0.311g MgCl 2 ·6H 2 O, 39mL 1.0M HCl, 0.292g CaCl 2 , 0.072g Na 2 SO 4 , 6.118g NH 2 C(CH 2 Oh) 3 (Tris) was added to deionized water at 37°C in order to obtain a colorless and transparent solution. Add deionized water to bring the solution to 900mL, measure the pH value of the solution at this time, and add 1.0M-HCl or Tris (2 -amino-2-(hydroxymethyl)-1,3-propanediol) to adjust the pH value of the solution to 7.40, and finally use a volumetric flask to set the volume to 1000mL to obtain a simulated body fluid solution.

[0035] (2) In a constant temperature water bath at 37°C, under stirring conditions, mix 1MK 2 HPO 4 ·3H 2...

Embodiment 2

[0039] A method for preparing hydroxyapatite nanoneedles, comprising the following steps:

[0040] (1) Take 700mL of deionized water and add it to a 1000mL plastic beaker, put it in a collector type magnetic stirrer, oil bath, magnetic stirring, set the temperature at 37°C. 8.035g NaCl, 0.355g NaHCO 3 , 0.225g KCl, 0.231g K 2 HPO 4 ·3H 2 O, 0.311g MgCl 2 ·6H 2 O, 39mL 1.0M HCl, 0.292g CaCl 2 , 0.072g Na 2 SO 4 , 6.118g NH 2 C(CH 2 Oh) 3 Add (Tris) to 37°C deionized water in order to obtain a colorless and transparent solution, add deionized water to make the solution to 900mL, measure the pH value of the solution at this time, and add 1.0M-HCl or Tris (2 -amino-2-(hydroxymethyl)-1,3-propanediol) to adjust the pH value of the solution to 7.40, and finally use a volumetric flask to set the volume to 1000mL to obtain a simulated body fluid solution.

[0041] (2) In a constant temperature water bath at 37°C, under stirring conditions, mix 1MK 2 HPO 4 ·3H 2 30ml of O...

Embodiment 3

[0045] A method for preparing hydroxyapatite nanoneedles, comprising the following steps:

[0046] (1) Take 700mL of deionized water and add it to a 1000mL plastic beaker, put it in a collector type magnetic stirrer, oil bath, magnetic stirring, set the temperature at 37°C. 8.035g NaCl, 0.355g NaHCO 3 , 0.225g KCl, 0.231g K 2 HPO 4 ·3H 2 O, 0.311g MgCl 2 ·6H 2 O, 39mL 1.0M HCl, 0.292g CaCl 2 , 0.072g Na 2 SO 4 , 6.118g NH 2 C(CH 2 Oh) 3 Add (Tris) to 37°C deionized water in order to obtain a colorless and transparent solution, add deionized water to make the solution to 900mL, measure the pH value of the solution at this time, and add 1.0M-HCl or Tris (2 -amino-2-(hydroxymethyl)-1,3-propanediol) to adjust the pH value of the solution to 7.40, and finally use a volumetric flask to set the volume to 1000mL to obtain a simulated body fluid solution.

[0047] (2) In a constant temperature water bath at 37°C, under stirring conditions, mix 1MK 2 HPO 4 ·3H 2 30ml of O...

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Abstract

The invention discloses a preparation method for synthesizing hydroxyapatite nanoneedles by a simulated body fluid method. The preparation method is characterized in that rod-shaped hydroxyapatite nanoneedles are synthesized by using simulated body fluid as a reaction solvent, CaCl2 as a calcium source and K2HPO4.3H2O as a phosphorus source under the condition of a P / Ca ratio of 1.5-1.6, wherein the widths of the nanoneedles are about 2-20nm, and the lengths of the nanoneedles are 50-80nm. The hydroxyapatite nanoneedles prepared by the method have the advantages of no need of pH regulation, no need of subsequent high-temperature sintering, short reaction time, similarity to hydroxyapatite in the teeth of the human body, adsorbent activity to dental bacteria, no toxic and side effects and significance to the health care of the oral cavity.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a method for preparing a hydroxyapatite nanoneedle and the hydroxyapatite nanoneedle prepared by the method. Background technique [0002] Hydroxyapatite is an important component of biological bone tissue, providing the necessary strength and hardness for bone. Synthetic hydroxyapatite has excellent biocompatibility, bioactivity, osteoconductivity and no biotoxicity, so it is widely used in medical fields such as bone replacement and bone repair. [0003] At present, there are many ways to synthesize hydroxyapatite, but the process of synthesizing hydroxyapatite requires high pH value, high reaction temperature, and long reaction time, and the product needs subsequent sintering treatment, and the synthesized hydroxyapatite is crystallizing The properties and structural stability are higher than that of hydroxyapatite in natural bone, and it is not easy ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): C01B25/32B82Y30/00
Inventor莫祥银丁林飞金传伟丁毅孙卫斌
OwnerNANJING NORMAL UNIVERSITY