Application of Houttuynoid B in medicine for preventing and treating liver injury

A liver injury and drug technology, applied in the field of Houttuynoid B, can solve problems such as liver damage, aggravation, and elevation, and achieve the effect of outstanding substantive characteristics and strong therapeutic effect.

Inactive Publication Date: 2013-01-16
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intravenous nutrition, etc., can all cause liver dam

Method used

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  • Application of Houttuynoid B in medicine for preventing and treating liver injury
  • Application of Houttuynoid B in medicine for preventing and treating liver injury
  • Application of Houttuynoid B in medicine for preventing and treating liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of compound Houttuynoid B tablet involved in the present invention:

[0012] Take 20 grams of compound Houttuynoid B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Houttuynoid B capsules involved in the present invention:

[0014] Take 20 grams of compound Houttuynoid B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

[0016] The following are some pharmacological experimental data:

experiment example 1

[0017] Experimental example 1. The effect of Houttuynoid B on prevention and treatment of liver injury

[0018] (1) Protective effect of Houttuynoid B on D-galactosamine (D-GalN)-induced acute liver injury in mice

[0019] The mice were divided into 5 groups, and the control group was intragastrically administered with normal saline (0.3 mL·d -1 ), for 7 consecutive days, on the 7th day intraperitoneal injection of normal saline (0.15mL·10g -1 ); D-GalN, Houttuynoid B (1.5, 3.0, 6.0 mg·kg -1 ) Each group was given intragastric administration of normal saline and different concentrations of Houttuynoid B (0.3 mL·d -1 ), for 7 consecutive days, on the 7th day intraperitoneal injection of D-GalN (800mg·kg -1 , 0.15mL·10g -1 ), blood was collected after 16 hours, and AST and ALT activities were measured.

[0020] Table 1 Protective effect of Houttuynoid B on acute liver injury induced by D-GalN

[0021]

[0022] Note: 1) p2) p<0.01 vs D-GalN group

[0023] It can be se...

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PUM

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Abstract

According to the pharmacological study on Houttuynoid B, the inventor discovers that Houttuynoid B has a protective effect on the D-galactosamine (D-GalN) induced mice acute liver injury and the CCl4 induced mice acute liver injury. Thus, the Houttuynoid B can be used for preparing a medicine for preventing and treating liver injury or hepatitis. The application of Houttuynoid B in preparing a medicine for treating liver injury is disclosed for the first time; and since the skeleton type is a brand new one and the activity in treating liver injury is unexpectedly strong, the possibility of any other compound offering any inspiration does not exist, outstanding substantial characteristics are obtained, and an obvious progress is made in resisting liver injury.

Description

technical field [0001] The present invention relates to Houttuynoid B, in particular, relates to Houttuynoid B used as medicine for preventing and treating liver damage. technical background [0002] There are multiple reasons for causing liver damage: 1. Viral infection: caused by a variety of hepatitis viruses, with strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. 2. Drugs or chemical poisons: Many drugs and chemical poisons can cause liver damage, drug-induced hepatitis or toxic hepatitis. 3. Alcoholism: Alcohol damages the liver very seriously. The consequences of the damage include alcoholic hepatitis, alcoholic fatty liver, and alcoholic cirrhosis, mainly due to the toxicity of alcohol (ethanol) and its metabolite acetaldehyde on liver cells. caused by direct damage. 4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intrav...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/16
Inventor 黄晨吴俊艺吴俊华
Owner NANJING UNIV
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