Chinese medicinal active ingredient with effect of treating diabetes mellitus

A technology of active ingredients and active ingredients, which is applied in the fields of traditional Chinese medicine, endocrinology and molecular pharmacology, can solve problems such as short half-life, and achieve the effect of exact curative effect, low price and long history.

Inactive Publication Date: 2013-01-30
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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AI Technical Summary

Problems solved by technology

However, endogenous GLP-1 and GIP have short half-lives and are typically degraded within minutes by dipeptidyl peptidase 4 (DPP-4) in vivo

Method used

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  • Chinese medicinal active ingredient with effect of treating diabetes mellitus
  • Chinese medicinal active ingredient with effect of treating diabetes mellitus
  • Chinese medicinal active ingredient with effect of treating diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] 1. Type 2 diabetes model animal hypoglycemic effect experiment:

[0019] SPF grade C57 / BL6 mice weighing 18-20 g were used and randomly divided into 4 groups with 6 mice in each group. The animal experiment groups are shown in Table 1.

[0020] Table 1. Animal experiment grouping design (the number is designed for a single experiment, repeated 3 times in total)

[0021]

[0022] They were the control group (con, fed with common feed, administered with PBS blank), the control group (con / gen, fed with common feed, administered with geniposide 100 mg / kg), and the diabetes model group (diabetes, administered with high-fat feed). After HFD ((hige fat diet, 63.47% of calories come from fat)) for 8 weeks, intraperitoneal injection of streptozotocin (STZ) streptozotocin 30 mg / kg, PBS blank control). Diabetes model treatment group (diab / gen, same as HFD feeding, STZ modeling, 100mg / kg geniposide administration). After modeling, the blood sugar level was monitored every day...

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Abstract

Jasminoidin serving as a GLP-1 (Glucagon-Like Peptide-1) receptor stimulating agent plays a role in protecting pancreatic beta cells. The invention belongs to the field of combination of traditional Chinese pharmacology, endocrinology and molecular pharmacology, and particularly relates to specific activation of a glucagon-like peptide-1 receptor (GLP-1R) signal channel through jasminoidin for prompting the survival of pancreatic beta cells and realizing a hypoglycemic effect. Mouse primary pancreatic beta cells are cultured by adopting a hypoglycemic Chinese medicinal jasminoidin active ingredient, so that beta cell proliferation can be promoted remarkably, apoptosis is inhibited, and beta apoptosis rate in a high-sugar or inflammatory factor environment is lowered simultaneously. Through a siRNA (small interfering Ribonucleic Acid) experiment, the expression of the GLP-1R in beta cells is lowered, and the protecting effect of jasminoidin on beta cells is inhibited. The invention discloses the effect of jasminoidin serving as a GLP-1 stimulating agent for protecting pancreatic cells by specifically activating a GLP-1R channel, explains the molecular pharmacological mechanism of jasminoidin on the treatment of diabetes mellitus, and lays a theoretical foundation for treating diabetes mellitus with the traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the field of combining traditional Chinese medicine, endocrinology and molecular pharmacology, and specifically relates to geniposide, an active ingredient of the traditional Chinese medicine Gardenia jasminoides, which acts as a glucagon-like peptide-1 receptor (GLP -1R) agonist, by specifically activating the GLP-1R signaling pathway, by protecting the survival of islet cells, and then achieve the effect of reducing the blood sugar level of diabetic model mice, on this basis can be further developed to treat diabetes containing geniposide medicine. Background technique [0002] In recent years, Diabetes Mellitus, especially Type 2 Diabetes Mellitus (T2DM), has become one of the three non-communicable diseases with the highest morbidity and mortality alongside cardiovascular diseases and tumors. β-cell failure is the core link in the pathogenesis of diabetes and the pathophysiological basis for the occurrence and development ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K31/7048A61P3/10
Inventor 舒娈贾晓斌韦英杰
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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