Nanoscale detection chip

A detection chip, nano-scale technology, applied in the direction of biochemical instruments, biochemical equipment and methods, enzymology/microbiology devices, etc., can solve problems such as easy to leave residues, easy to damage samples, expensive, etc., to achieve processing methods The effect of fast, fast sequencing, and accurate cost

Inactive Publication Date: 2013-02-06
沈阳市东陵区(浑南新区)卓科技术开发中心
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Problems solved by technology

But this method is expensive, easy to damage the sample, and the process of sample preparation is very slow
The chemical etching method corrodes a certain sample to form a channel through the chemical reaction between the chemical solution and the sample, but this method is difficult to control the parameters and uniformity of the etched channel, and it is easy to leave residues and cause pollution

Method used

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  • Nanoscale detection chip

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Embodiment Construction

[0018] The present invention will be described in detail below in conjunction with the accompanying drawings.

[0019] figure 1 It is the nanofluidic chip structure of the present invention, wherein the part indicated by 1 is an electrode, and 5 pairs of electrodes are designed on the chip, 2 is a nanotube processed by AFM, 3 is a micron tube, 4 is a liquid storage pool, and 5 is a liquid storage pool Electrode, 6 is a single liquid reservoir electrode.

[0020] The processing method is

[0021] 1) Design nanofluidic chip: design and process such figure 1 In the shown nanofluidic chip, the unconnected area in the middle of the micro-pipe 3 is the area to be processed, which is used for subsequent processing of the nano-pipe 2 by using the AFM processing method. In the chip structure, the electrode 1 can be used to detect and analyze the signal of the nano-object solution in the nano-pipe 2;

[0022] 2) AFM processing of nanopipes: by controlling the AFM probe to press into...

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Abstract

The invention discloses a nanoscale detection chip. Two liquid storage tanks are respectively arranged on the two ends of the chip, each liquid storage tank is connected with a micrometer pipeline, a nanometer pipeline is arranged between the two micrometer pipelines, and the two sides of the nanometer pipeline are respectively provided with an electrode which is vertical to the nanometer pipeline; and the liquid storage tanks are rectangular, and a plurality of electrodes which are vertical to the liquid storage tanks are arranged on one sides of the liquid storage tanks. The chip can accurately apply current and voltage according to different detection requirements, so that only one group of the electrodes can be prevented from influencing the current when generating the regulation voltage.

Description

technical field [0001] The invention relates to a detection instrument, in particular to a nanoscale detection chip. Background technique [0002] Nanopipes refer to tiny pipes with at least one dimension at the nanoscale. Nanopipes have many advantages in the field of nanofluidic research. Because the size of nanotubes is on the nanoscale, it can be used to study novel physical properties of liquids and gases in such tiny tubes. Compared with nanopores, nanopipes have a longer one-dimensional scale, so that the liquid in the pipes can have a slower flow rate, thus improving the resolution of detection. At the same time, multiple detection points can be set on both sides of the nanopipe, which is helpful for high-sensitivity and multi-point detection of the characteristics of objects in the pipeline. Nanofluidic chips containing nanopipes can be widely used in high-sensitivity detection and manipulation of small nano-objects, such as biomolecular detection and single DNA m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34
Inventor 任凯
Owner 沈阳市东陵区(浑南新区)卓科技术开发中心
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