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Andrographis paniculata extract and method for preparing same

A technology of andrographis paniculata and extract, applied in the field of andrographis paniculata extract and preparation thereof, can solve the problems of difficulty in retaining andrographis paniculata effective components, not removing impurity components, affecting the quality of andrographis paniculata preparations, etc. The effect of industrial mass production

Inactive Publication Date: 2014-09-03
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current industrialized production, single-effect or double-effect thermal concentration process and drying process are used for concentration. Therefore, the active ingredient in the Churographis paniculata tablets produced according to the Pharmacopoeia process - the total andrographolide component has been eliminated in the production process. ("Changes in content of dehydroandrographolide in the production process of Chuanxinlian tablets", Chinese Journal of Traditional Chinese Medicine, 2002, 12, 36-38), it can be seen that this simple production technology not only does not remove impurities, but also It is difficult to keep the active ingredients in Andrographis paniculata, which has seriously affected the quality of Andrographis paniculata preparations. For this reason, further research on how to effectively improve the yield of active ingredients such as andrographolide and the large-scale production preparation technology for removing impurity components such as pigments to the greatest extent is necessary. It is very important to ensure the quality and curative effect of Andrographis paniculata preparation

Method used

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  • Andrographis paniculata extract and method for preparing same
  • Andrographis paniculata extract and method for preparing same
  • Andrographis paniculata extract and method for preparing same

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Take 10kg of Andrographis paniculata, first crush it into coarse grains, then ball mill it into superfine powder particles, extract twice by percolation with 10 times the weight of 85% ethanol (v / v), each extraction time is 24h; after the extraction, filter, The two filtrates were combined to obtain Andrographis paniculata extract, which was filtered through a microfiltration membrane (using PP cotton) to remove suspended particles and other impurities. At the same time, it can be seen that PP cotton adsorbed a large amount of pigments and other components; the filtrate was purified by activated carbon fiber column, further Impurities such as pigments are removed, and the purified solution is driven by a high-pressure pump (the working pressure of the high-pressure pump is kept between 0.6 and 0.9 MPa), and the Andrographis paniculata extract is concentrated by nanofiltration membrane circulation and pressure to 1 / 10 of the original volume , the obtained concentrated sol...

Embodiment 2

[0036]Take 50 kg of Andrographis paniculata, first crush it into coarse grains, and then ball mill it into superfine powder particles, extract twice by cold soaking in 85% ethanol (v / v) with 10 times the weight, and the extraction time is 24 hours each time; after the extraction, filter, The two filtrates were combined to obtain Andrographis paniculata extract, which was filtered through a microfiltration membrane (using PP cotton) to remove suspended particles and other impurities. At the same time, it can be seen that PP cotton adsorbed a large amount of pigments and other components; the filtrate was purified by activated carbon fiber column, further Impurities such as pigments are removed, and the purified solution is driven by a high-pressure pump (the working pressure of the high-pressure pump is kept between 0.6 and 0.9 MPa), and the Andrographis paniculata extract is concentrated by nanofiltration membrane circulation and pressure to 1 / 10 of the original volume , the ob...

Embodiment 3

[0038] Take 5 kg of Andrographis paniculata, first crush it into coarse grains, and then ball mill it into superfine powder particles, extract twice by percolation with 85% ethanol (v / v) of 10 times the weight, and the extraction time is 24 hours each time; after the extraction, filter, The two filtrates were combined to obtain Andrographis paniculata extract, which was filtered through a microfiltration membrane (using PP cotton) to remove suspended particles and other impurities. At the same time, it can be seen that PP cotton adsorbed a large amount of pigments and other components; the filtrate was purified by activated carbon fiber column, further Impurities such as pigments are removed, and the purified solution is driven by a high-pressure pump (the working pressure of the high-pressure pump is kept between 0.6 and 0.9 MPa), and the Andrographis paniculata extract is concentrated by nanofiltration membrane circulation and pressure to 1 / 10 of the original volume , the obt...

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Abstract

The invention discloses an extract of andrographis paniculata and a preparation method thereof. The extract contains 32.3-40.5 percent by mass of andrographolide and 2.23-5.52 percent by mass of dehydroandrographolide. The preparation method comprises the following steps: crushing andrographis paniculata by ball milling technology, extracting with ethanol, filtering the obtained extract through microfiltration membrane, purifying with active carbon fiber, concentrating with nanofiltration membrane, eluting with macroporous resin, and spray drying. The Andrographis paniculata extract prepared by the present invention retains the active ingredient andrographolide and other components of the Andrographis paniculata to a great extent, removes impurity components such as pigments in the Andrographis paniculata, and maintains its strong antibacterial and anti-inflammatory activity. The preparation method of the invention is simple to operate, does not need heating, has low production energy consumption, and is suitable for industrialized batch production.

Description

Technical field [0001] The present invention involves the preparation method of drugs that derive from plant raw materials, and specifically involves a lotus lotus extract and their preparation methods. Background technique [0002] Putting heart lotus medicinal materials for Juemidae Androidraphis Paniculata (BURM.F.) The whole grass of Nees has the effects of clearing heat and detoxifying, cooling blood and swelling. It is widely distributed in Guangdong and has a long history of cultivation.It is a multi -famous medicinal material for wearing lotus injection, wearing auine, wearing a lotus tablets, anti -inflammatory tosses, compound heart lotus tablets and other famous Chinese medicines.Its active ingredients are ingredients such as wearing lotus larvae. In addition to such active ingredients, there are many types of chemical components such as pigment with low content.Activated ingredients such as wearing lotus are unstable and easy to decompose. Long -term heating will caus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/19A61P31/04
Inventor 曾令杰
Owner GUANGDONG PHARMA UNIV
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