Method for biotransformation of pseudo-ginseng by using Candida

A technology of Candida and Candida, which is applied in the fields of cosmetics, food science, drug combination, etc., can solve the problems of obtaining, difficult to extract methods, and low content of secondary ginsenosides.

Active Publication Date: 2013-05-15
冯淑琴 +2
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Problems solved by technology

[0009] Due to the extremely low content of secondary ginseno...

Method used

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  • Method for biotransformation of pseudo-ginseng by using Candida
  • Method for biotransformation of pseudo-ginseng by using Candida
  • Method for biotransformation of pseudo-ginseng by using Candida

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Effects of Panax notoginseng transformation concentration, transformation time, inoculum size transformation conditions on transformation effect

[0026] Utilize the orthogonal test, design three factors including fermentation conversion time, the conversion concentration of Panax notoginseng and the inoculum amount of Candida lambica, each factor takes three levels (see Table 1 for details). Take the dried Panax notoginseng, crush it, pass through a 100-mesh sieve, and combine 9 samples according to the design of the orthogonal experiment, and weigh the Panax notoginseng powder with different weights as shown in Table 1. After each sample was soaked in appropriate amount of drinking water for 3 hours, it was sterilized at 115°C for 40 minutes. To obtain different concentrations of Panax notoginseng transformation substrates, when the temperature drops to about 30°C, insert the pre-cultured Candida lambica liquid according to the inoculum size in Table 1, and...

Embodiment 2

[0039] Embodiment 2: Changes of Panax notoginseng total saponins before and after transformation of Candida lambicus

[0040] The change of total saponins of Panax notoginseng before and after transformation of Candida lambica was detected by spectrophotometry (technical specification for inspection and evaluation of health food: determination of total saponins in health food). As a result, it can be seen that compared with the unconverted total saponins, its content has increased by 66.10%.

[0041] Take the dried Radix Notoginseng, after pulverizing, pass through a 100-mesh sieve, accurately weigh the Radix Notoginseng powder, so that the Notoginseng concentration is 2.5% (weight / volume) of the total conversion volume. After soaking in appropriate amount of drinking water for 3 hours, sterilize under high pressure at 121°C for 40 minutes. When the temperature was cooled to about 30° C., the pre-cultured Candida lambica liquid was inserted so that the volume of the Candida l...

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Abstract

The invention relates to a method for biotransformation of the main component notoginsenoside in the traditional Chinese medicine pseudo-ginseng by using saccharomycete; specifically speaking, the invention relates to a method for biotransformation of notoginsenoside by using Candida, especially by using Candida lambica. After transformation by the saccharomycete, the content of panax notoginseng saponins, especially the content of rare ginsenosides like ginsenoside Rg3 and Rh2, is substantially increased. The notoginsenoside transformed by Candida lambica can be used as a raw material for production of medicines, health products or cosmetics.

Description

technical field [0001] The present invention relates to the biotransformation method of notoginseng saponin, which is the main component of traditional Chinese medicine Panax notoginseng, by yeast. Specifically, the present invention relates to the biotransformation method of notoginseng saponin by using Candida, especially Candida lambica . After the transformation of yeast, the content of total saponins of notoginseng, especially the content of rare ginsenosides such as ginsenoside Rg3 and Rh2 can be significantly increased. The notoginseng saponins transformed by Candida lambica can be used as raw materials for the production of medicine, health products or cosmetics. technical background [0002] Sanqi (Panax notoginseng (Burk.) F.H.Chen) is a plant of Araliaceae, which is used as medicine with its dried roots. Panax notoginseng is also known as mountain knee, field notoginseng, blood ginseng, ginseng notoginseng. Panax notoginseng has a long history of being used to ...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K8/97A61P39/06A61P37/04A61P9/00A61P25/00A61P3/00A61P29/00A61P35/00A61Q19/08A61Q19/00A23L1/29A23L33/00
Inventor 冯淑琴冯淑霞冯淑青
Owner 冯淑琴
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