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Use of cinnamon oil for preparing medicine for treating prostatic hyperplasia or alopecia seborrhoeica

A technology for benign prostatic hyperplasia and seborrheic alopecia, applied in the field of application of cinnamon oil in the preparation of medicines for treating benign prostatic hyperplasia or seborrheic alopecia, achieving the effect of clear drug effect, controllable quality, and relieving obstruction symptoms

Inactive Publication Date: 2013-05-22
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cause of the disease has not been fully clarified, and now medical research believes that genetic factors and dihydrotestosterone are the main factors leading to male pattern hair loss

Method used

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  • Use of cinnamon oil for preparing medicine for treating prostatic hyperplasia or alopecia seborrhoeica
  • Use of cinnamon oil for preparing medicine for treating prostatic hyperplasia or alopecia seborrhoeica
  • Use of cinnamon oil for preparing medicine for treating prostatic hyperplasia or alopecia seborrhoeica

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Experimental program
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Effect test

Embodiment 1

[0018] Embodiment 1 Preparation of cinnamon oil of the present invention

[0019] After crushing the cinnamon, weigh 500g and place it in a 2000ml flask, add 3 times of water and soak for 60min, then add 15% NaCl solution as an auxiliary agent, and heat to keep the system in a boiling state. Move the steamed cinnamon oil-water emulsion into a centrifuge, and centrifuge at 4000r / min. Drain the water in the upper layer to obtain the volume of cinnamon oil. The yield of cinnamon volatile oil was 2.13%. Detected by HPLC, the cinnamaldehyde content is 83.56%. Its HPLC spectrum is as figure 1 shown.

[0020] Except adopting the cinnamon oil extraction method of the present invention to prepare, also can adopt supercritical fluid (CO 2 ) extraction method (He Cuiwei, orthogonal test optimal supercritical fluid CO of cinnamon aldehyde in cinnamon 2 ) extraction and GC-MS analysis, Journal of Guangxi College of Traditional Chinese Medicine, 2007, Volume 10, No. 1), steam distilla...

Embodiment 3

[0049] Embodiment 3 Cinnamon oil of the present invention treats the clinical observation of seborrheic alopecia and its determination of serum dihydrotestosterone

[0050] 1. Case selection Inclusion criteria: 20-45 years old seborrheic alopecia patients, Norwood / Hamilton grade III-V, all have parietal alopecia. Exclusion criteria: patients with hypertension (blood pressure over 140 / 90mmHg for 3 consecutive time points) or patients with a history of heart, liver, kidney, endocrine, or psychological diseases; patients with scalp seborrheic dermatitis, psoriasis or scalp infection ; Received the drugs in this study, hair growth agents and drugs that may interfere with hair growth (antihypertensive drugs, systemic use of corticosteroids, cytotoxic agents, antiepileptic drugs, broncho and vasodilators) within the first 6 months of patients.

[0051] 2. General situation

[0052] The 61 patients were randomly divided into two groups according to the treatment sequence. There we...

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Abstract

The invention provides use of cinnamon oil for preparing a medicine for treating prostatic hyperplasia or alopecia seborrhoeica. The invention further provides a pharmaceutical composition for treating prostatic hyperplasia or alopecia seborrhoeica. For treating prostatic hyperplasia or alopecia seborrhoeica, the cinnamon oil disclosed by the invention is clear in efficacy and strong in controllability, therefore, a new choice is provided in clinical.

Description

[0001] This application is a divisional application of a patent application with filing date: January 25, 2010, application number: 201010100520.1, and title of invention: the use of cinnamon oil in the preparation of 5α-reductase inhibitor drugs. technical field [0002] The invention provides a new application of the cinnamon oil, specifically, the application in the preparation of medicines for treating benign prostatic hyperplasia or seborrheic alopecia. Background technique [0003] 5α-reductase inhibitors are an important class of drugs for the treatment of benign prostatic hyperplasia, male pattern baldness, and female hirsutism. 5α-reductase inhibitors are new drugs for the treatment of benign prostatic hyperplasia that have been marketed in recent years. 5α-reductase is widely present in the prostate and other tissues and organs. It is a catalytic enzyme that converts testosterone into dihydrotestosterone, and testosterone and dihydrotestosterone have different effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P17/14A61P13/08A61K129/00
Inventor 马松涛刘冬恋廖昌军
Owner CHENGDU MEDICAL COLLEGE
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