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Application of preparing statins aerosol inhalant in airway inflammation disease

An aerosol, statin technology, applied in the field of pharmaceutical preparations, can solve problems such as increasing oral doses, increasing the risk of clinical drug adverse events, and increasing bioavailability

Inactive Publication Date: 2013-06-05
谢诒诚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the oral adverse reactions of statins mentioned above, we believe that increasing the oral dose or increasing the bioavailability may increase the risk of clinical adverse drug events, so we designed the way of aerosol administration to reduce the blood of statins. drug concentration increases its local lung concentration

Method used

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  • Application of preparing statins aerosol inhalant in airway inflammation disease
  • Application of preparing statins aerosol inhalant in airway inflammation disease
  • Application of preparing statins aerosol inhalant in airway inflammation disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Component Weight Percentage (%)

[0024] Simvastatin 200 mg 1.23

[0025] Ethanol 3.0 g 18.51

[0026] Oleic acid 6 mg 0.04

[0027] HFA-134a 13 g 80.22

[0028] After dissolving simvastatin, ethanol and oleic acid, the two-step method is filled with HFA-134a to obtain the product.

Embodiment 2

[0030] Component Weight Percentage (%)

[0031] Lovastatin 200 mg 1.23

[0032] Ethanol 3.0 g 18.51

[0033] Oleic acid 6 mg 0.04

[0034] HFA-134a 13 g 80.22

[0035] After dissolving simvastatin, ethanol and oleic acid, the two-step method is filled with HFA-134a to obtain the product.

Embodiment 3

[0037] Component Weight Percentage (%)

[0038] Pravastatin 200 mg 1.23

[0039]Ethanol 3.0 g 18.51

[0040] Oleic acid 6 mg 0.04

[0041] HFA-134a 13 g 80.22

[0042] After dissolving simvastatin, ethanol and oleic acid, the two-step method is filled with HFA-134a to obtain the product.

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Abstract

The invention discloses an application of manufacturing statins gas spray in airway inflammation disease. The aerosol refers to a non-chlorofluorocarbon (CFC) solution formula. The fine subfraction (FPF) of the formula is high. The result display of a gas spray inhalant thermodynamic experience is quick and the effect is high so as to be used for treating bronchial asthma and a chronic obstructive pulmonary disease (COPD). The aerosol inhalant has the advantages of being good in anti-inflammation of airway and reducing adverse reaction caused by oral large doses.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of a statin quantitative inhalation aerosol and the application of other statin drug aerosol inhalation in airway inflammatory diseases. Background technique [0002] Statins drugs are hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, including the natural compound simvastatin (English name: simvastatin, aliases: Zocor, Lishuda, Suzhi, Ze Zhihao, Xinke), lovastatin (English name: lovastatin, alias: Meijiangzhi, Luo Huaning, Luote, Luozhite, Mingweixin), pravastatin (English name: pravastatin, alias: Pragu , Mei Baile Town) and completely synthetic compounds fluvastatin (English name: fluvastatin, alias: Laishike), atorvastatin (English name: atovastatin, alias: Lipitor, Ale), Cerivar Statin (English name: cerivastatin), pitavastatin (English name: pitavastatin), rosuvastatin (English name: rosuvastatin), etc., have been wid...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/22A61K31/366A61K31/40A61K31/405A61K31/4418A61K31/47A61K31/4709A61K31/505A61P11/00A61P11/06
Inventor 谢诒诚董新威贾永良
Owner 谢诒诚
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