Human big cell lung cancer cell strain with high osseous metastasis potency

Abstract

The invention belongs to the field of biotechnology and microorganism animal cell line and particularly relates to a human big cell lung cancer cell strain with high osseous metastasis potency and a purpose of the human big cell lung cancer cell strain with high osseous metastasis potency. A human big cell lung cancer parental generation cell NCI-H460 is utilized as a source cell for screening an osseous metastasis cell, the human big cell lung cancer cell line H460BM with high osseous metastasis potency is screened, cultivated and built by screening six times inside and outside an immunodeficient mice. A preservation number is CGMCC No. 5406. The cell line can be used as an ideal cell model of directional osseous metastasis research of human lung cancer and for transformation mechanism research and anti-metastasis drug screening of human cancer.

Description

technical field [0001] The invention belongs to the fields of biological technology and microbial animal cell lines, and specifically relates to a human large cell lung cancer cell line with high bone metastasis potential and its application. Background technique [0002] Lung cancer is one of the malignant diseases that seriously threaten the survival and development of human beings, and has become the number one killer of tumor diseases. Although the current clinical treatment of lung cancer has made great progress, statistics show that the mortality rate of lung cancer is still high for a long time; the main reason for the research analysis is that the disease is difficult to diagnose early and its high metastases. Clinical practice shows that many patients are found to have multiple organ metastases at the first diagnosis. Therefore, tumor metastasis and recurrence are still difficult problems in the treatment of lung cancer; however, at present, lung cancer metastasis, ...

AI Technical Summary

Problems solved by technology

Although the current clinical treatment of lung cancer has made considerable progress, statistics show that the mortality rate of lung cancer is still high for a long time; the main reasons for the research analysis are that the disease is difficult to diagnose early and its high metastases

Clinical practice shows that many patients are found to have multiple organ metastases when they are first diagnosed. Therefore, tumor metastasis and recurrence are still difficult problems in the treatment of lung cancer; however, at present, lung cancer metastasis, especially targeted metastasis (transfer of tumor cells to specific organs) The molecular mechanism is still unclear

Statistics show that the incidence of lung cancer is increasing year by year, and it is very easy to metastasize to bone, brain, and liver, and the prognosis of patients is very poor.

At present, studies on tumor metastasis-related molecules have discovered various molecules, such as molecules that degrade cell matrix, cell adhesion molecules, and metastasis-associated glycoproteins, etc., but none of the above studies have investigated the mechanism of tumor metastasis to specific organs illustrate

Images