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Novel extraction and purification technology for 5-hydroxytryptophan

A new technology of hydroxytryptophan, which is applied in the field of new extraction and purification process of 5-hydroxytryptophan, can solve the problems of lethality, 5-hydroxytryptophan is easily polluted, and cannot be industrialized.

Inactive Publication Date: 2013-06-12
李玉山
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Problems solved by technology

However, the synthetic 5-hydroxytryptophan is easily contaminated during the fermentation process, and there have been fatal incidents of contaminated products in Japan
[0006] Chemical synthesis and microbial methods are limited to theory and cannot be produced industrially at present. The preparation of 5-hydroxytryptophan is still done by extracting from Ghana seeds in Africa

Method used

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  • Novel extraction and purification technology for 5-hydroxytryptophan

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Embodiment Construction

[0015] Method 1: 1. Pressing: Take 600kg Ghanaian seeds and press them with LYZ×24 low-temperature screw oil press. When feeding less and then more, gradually increase the amount. It is forbidden to feed too quickly. Keep poking the material door to prevent material breakage. The time of material breakage or downtime generally does not exceed 5 minutes. 12r / min, when the temperature rises to 35°C, adjust to 10r / min, and adjust the thickness of the cake to about 10mm in 2 to 3 times, and the current of the host is 35 to 40A. 2. Extraction: Take 500kg of pressed cake and put it into a multifunctional extraction tank, add 3000kg of 80% methanol to extract at 60°C for 2 hours, soak for 1 hour before extraction, and filter the extract. The filter residue was then extracted with 2000kg of 80% methanol at 60°C for 1.5h, and the extract was filtered. The filter residue was then extracted with 1500kg of 80% methanol at 60°C for 1.0h. 3. Concentration: the three extracts were concentra...

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Abstract

The invention provides a novel extraction and purification technology for 5-hydroxytryptophan. The novel extraction and purification technology mainly comprises the following steps of: (1) squeezing griffonia simplicifolia seeds to remove oil; (2) extracting cake feeds; (3) concentrating an extracting solution, and degreasing; (4) crystallizing a concentration solution; (5) centrifuging crystal substances and drying; and (6) preprocessing crystallizing mother liquor. Especially, the crystallizing mother liquor is treated by four methods, so that scarce resources are effectively utilized, and the yield is increased, and the total yield can be up to 12.5%. An anti-oxidant treatment technology is adopted in squeezing and extraction processes; the novel extraction and purification technology is advanced and unique, has the advantages of mild extraction conditions, high extraction ratio, low production cost, high yield and simple and convenient operation, and is environment-friendly and suitable for industrial production; and raw materials are saved in the whole productive process.

Description

technical field [0001] The invention relates to a novel extraction and purification process for 5-hydroxytryptophan. Background technique [0002] 5-hydroxytryptophan (5-hydroxytryptophan), is a natural amino acid extracted from the seeds of the African legume plant Griffonia simplicifolia, molecular formula: C 11 h 12 N 2 0 3 , molecular weight: 220.23. The seeds are oblong, about 1.5 cm long, and about 1 cm wide. The seed coat is black and wrinkled, the endosperm is yellow-green, with a slight bean flavor, and the dry fruit weighs about 80 grams. It is wild in Ghana, Ivory Coast and Togo in Africa Wait for West African countries. 5-Hydroxytryptophan is a pure natural herbal prescription with sedative effect. It is a precursor substance of a hormone (serotonin) in the human body, which can help the human body produce this hormone to achieve balance in the body. It affects our mood, sleep and appetite, and when the serotonin in the brain is unbalanced, 5-hydroxytryptop...

Claims

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Application Information

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IPC IPC(8): C07D209/20
Inventor 李玉山
Owner 李玉山
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